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Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma

Ying Liu,  Yu Han,  Shizhu Chen,  Jingjie Liu,  Dajiang Wang,  Yifei Huang

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Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang. Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma[J]. 机械工程学报. doi: 10.1016/j.apsb.2021.10.009
引用本文: Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang. Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma[J]. 机械工程学报. doi: 10.1016/j.apsb.2021.10.009
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Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang. Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma[J]. JOURNAL OF MECHANICAL ENGINEERING. doi: 10.1016/j.apsb.2021.10.009
Citation: Ying Liu, Yu Han, Shizhu Chen, Jingjie Liu, Dajiang Wang, Yifei Huang. Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma[J]. JOURNAL OF MECHANICAL ENGINEERING. doi: 10.1016/j.apsb.2021.10.009
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Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma

doi: 10.1016/j.apsb.2021.10.009

  • a. Department of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China;

  • b. Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China;

  • c. College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China;

  • d. China Resources Pharmaceutical Group Limited, Beijing 100000, China

基金项目: 

This research was financially supported by National Natural Science Foundation of China (7212092, 81770887), China Postdoctoral Science Foundation (2019M650558), Beijing Postdoctoral Research Foundation and Beijing Chaoyang District Postdoctoral Research Foundation.

详细信息
    通讯作者:

    Dajiang Wang,E-mail:glaucomawang@163.com

    Yifei Huang,E-mail:yfhuang301@163.com

  • 中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383521004019/pdf?md5=7090ecb111f0cf6b0a6671b1b7500b63&pid=1-s2.0-S2211383521004019-main.pdf

Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma

  • a. Department of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China;

  • b. Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China;

  • c. College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China;

  • d. China Resources Pharmaceutical Group Limited, Beijing 100000, China

Funds: 

This research was financially supported by National Natural Science Foundation of China (7212092, 81770887), China Postdoctoral Science Foundation (2019M650558), Beijing Postdoctoral Research Foundation and Beijing Chaoyang District Postdoctoral Research Foundation.

    摘要
  • 摘要: Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG in vivo, but also realized imaging-guide photothermal therapy, which created a new strategy for the treatment of retinoblastoma.

     

    Abstract: Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG in vivo, but also realized imaging-guide photothermal therapy, which created a new strategy for the treatment of retinoblastoma.

     

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出版历程
  • 收稿日期:  2021-08-30
  • 修回日期:  2021-10-06
  • 录用日期:  2021-10-08
  • 网络出版日期:  2023-03-17

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