Development and clinical advancement of small molecules for <i>ex vivo</i> expansion of hematopoietic stem cell

Jiaxing Li; Xiao Wang; Jiayu Ding; Yasheng Zhu; Wenjian Min; Wenbing Kuang; Kai Yuan; Chengliang Sun; Peng Yang

doi:10.1016/j.apsb.2021.12.006

Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

doi: 10.1016/j.apsb.2021.12.006

a. State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China;
b. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

基金项目:

This study was supported by National Natural Science Foundation of China (82073701, 31900687), Natural Science Foundation of Jiangsu Province (SBK2019040713, China) and the Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University (SKLNMZZ202013, China). This study was also supported by Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University (No. 2020KFKT-5, China), and “Double First-Class” University Project (CPU2018GF04, China).

详细信息

通讯作者:
Peng Yang,E-mail:pengyang@cpu.edu.cn

中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383521004780/pdf?md5=e7807dd77c1d301d0f4953c3ac1edb9a&pid=1-s2.0-S2211383521004780-main.pdf
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出版历程
- 收稿日期: 2021-10-17
- 修回日期: 2021-12-02
- 录用日期: 2021-12-09
- 网络出版日期: 2023-03-17

Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

Jiaxing Li^a,b,
Xiao Wang^a,b,
Jiayu Ding^a,b,
Yasheng Zhu^a,b,
Wenjian Min^a,b,
Wenbing Kuang^a,b,
Kai Yuan^a,b,
Chengliang Sun^a,b,
Peng Yang^{a,b
, ,}

a. State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China;
b. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Funds:

摘要

摘要: Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs. Till now, several small-molecule compounds have entered the phase I/II trials, showing safe and favorable pharmacological profiles. As HSC expansion has become a hot topic over recent years, many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue. Here, we will give an overview of HSC biology, discovery and medicinal chemistry development of small molecules, natural products targeting for HSC expansion, and their recent clinical progresses, as well as potential protein targets for HSC expansion.
- HSC /
- Small molecule /
- Expansion /
- Clinical /
- Targets
Abstract: Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs. Till now, several small-molecule compounds have entered the phase I/II trials, showing safe and favorable pharmacological profiles. As HSC expansion has become a hot topic over recent years, many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue. Here, we will give an overview of HSC biology, discovery and medicinal chemistry development of small molecules, natural products targeting for HSC expansion, and their recent clinical progresses, as well as potential protein targets for HSC expansion.
- HSC /
- Small molecule /
- Expansion /
- Clinical /
- Targets

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参考文献(174)

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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

doi: 10.1016/j.apsb.2021.12.006

通讯作者:
Peng Yang,E-mail:pengyang@cpu.edu.cn

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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

doi: 10.1016/j.apsb.2021.12.006

通讯作者: Peng Yang,E-mail:pengyang@cpu.edu.cn

计量

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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

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出版历程

目录

通讯作者:
Peng Yang,E-mail:pengyang@cpu.edu.cn