Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Zhiran Ju; Menglan Li; Junde Xu; Daniel C. Howell; Zhiyun Li; Fen-Er Chen

doi:10.1016/j.apsb.2022.01.002

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

doi: 10.1016/j.apsb.2022.01.002

a. Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China;
b. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai 200433, China;
c. Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China;
d. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China

基金项目:

The author would like to thank Dr. K. Kaliyaperumal, Dr. M. Fredimoses, and Dr. B. Sachin for their carful revisions of this work.

详细信息

通讯作者:
Fen-Er Chen,E-mail:rfchen@fudan.edu.cn

中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383522000156/pdf?md5=6b298e29b3d6ad3ff221c15e554d025e&pid=1-s2.0-S2211383522000156-main.pdf
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出版历程
- 收稿日期: 2021-11-16
- 修回日期: 2021-12-14
- 录用日期: 2021-12-30
- 网络出版日期: 2023-03-17

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

a. Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China;
b. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai 200433, China;
c. Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China;
d. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China

Funds:

The author would like to thank Dr. K. Kaliyaperumal, Dr. M. Fredimoses, and Dr. B. Sachin for their carful revisions of this work.

摘要

摘要: Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation. NSAIDs are the most frequent choices for treatment of inflammation. Nevertheless, currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal. Recently, more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles. In this review, we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011–2021. It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research.
- Inflammation /
- Cyclooxygenase /
- Prostaglandins /
- Adverse effects /
- COX-2 inhibitors
Abstract: Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation. NSAIDs are the most frequent choices for treatment of inflammation. Nevertheless, currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal. Recently, more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles. In this review, we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011–2021. It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research.
- Inflammation /
- Cyclooxygenase /
- Prostaglandins /
- Adverse effects /
- COX-2 inhibitors

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参考文献(113)

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Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

doi: 10.1016/j.apsb.2022.01.002

通讯作者:
Fen-Er Chen,E-mail:rfchen@fudan.edu.cn

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Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

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Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

doi: 10.1016/j.apsb.2022.01.002

通讯作者: Fen-Er Chen,E-mail:rfchen@fudan.edu.cn

计量

出版历程

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

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出版历程

目录

通讯作者:
Fen-Er Chen,E-mail:rfchen@fudan.edu.cn