Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

Shanmin Zheng; Jiawei Guo; Fangyuan Cheng; Zhengquan Gao; Lei Du; Chunxiao Meng; Shengying Li; Xingwang Zhang

doi:10.1016/j.apsb.2022.01.013

Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

doi: 10.1016/j.apsb.2022.01.013

a. School of Life Sciences, Shandong University of Technology, Zibo 255000, China;
b. State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China;
c. School of Pharmacy, Binzhou Medical University, Yantai 264003, China;
d. Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

基金项目:

This work was supported by the National Key Research and Development Program of China (2020YFA0907900), the National Natural Science Foundation of China (32000039, 32025001, 31972815 and 42176124), the Natural Science Foundation of Shandong Province (ZR2019ZD20, ZR2019ZD17 and ZR2020ZD23), the Fundamental Research Funds of Shandong University (2019GN031), and the Scientific Research Fund of Binzhou Medical University (BY2021KYQD25).

详细信息

通讯作者:
Chunxiao Meng,E-mail:mengchunxiao@126.com

Shengying Li,E-mail:lishengying@sdu.edu.cn

Xingwang Zhang,E-mail:zhangxingwang@sdu.edu.cn

中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383522000260/pdf?md5=d17c64b25edcb6ee7d080a20255823a1&pid=1-s2.0-S2211383522000260-main.pdf
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出版历程
- 收稿日期: 2021-11-08
- 修回日期: 2022-01-05
- 录用日期: 2022-01-17
- 网络出版日期: 2023-03-17

Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

a. School of Life Sciences, Shandong University of Technology, Zibo 255000, China;
b. State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China;
c. School of Pharmacy, Binzhou Medical University, Yantai 264003, China;
d. Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

Funds:

摘要

摘要: Algae are a large group of photosynthetic organisms responsible for approximately half of the earth's total photosynthesis. In addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life, algae are also a rich source of bioactive natural products, including several clinical drugs. Cytochrome P450 enzymes (P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of reactions. In the post-genome era, a growing number of P450 genes have been discovered from algae, indicating their important roles in algal life-cycle. However, the functional studies of algal P450s remain limited. Benefitting from the recent technical advances in algae cultivation and genetic manipulation, the researches on P450s in algal natural product biosynthesis have been approaching to a new stage. Moreover, some photoautotrophic algae have been developed into “photo-bioreactors” for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative manner. Here, we comprehensively review these advances of P450 studies in algae from 2000 to 2021.
- Natural product biosynthesis /
- Algal pharmaceuticals /
- Cytochrome P450 enzymes /
- Algae /
- Light-driven bioproduction
Abstract: Algae are a large group of photosynthetic organisms responsible for approximately half of the earth's total photosynthesis. In addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life, algae are also a rich source of bioactive natural products, including several clinical drugs. Cytochrome P450 enzymes (P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of reactions. In the post-genome era, a growing number of P450 genes have been discovered from algae, indicating their important roles in algal life-cycle. However, the functional studies of algal P450s remain limited. Benefitting from the recent technical advances in algae cultivation and genetic manipulation, the researches on P450s in algal natural product biosynthesis have been approaching to a new stage. Moreover, some photoautotrophic algae have been developed into “photo-bioreactors” for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative manner. Here, we comprehensively review these advances of P450 studies in algae from 2000 to 2021.
- Natural product biosynthesis /
- Algal pharmaceuticals /
- Cytochrome P450 enzymes /
- Algae /
- Light-driven bioproduction

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Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

doi: 10.1016/j.apsb.2022.01.013

通讯作者:
Chunxiao Meng,E-mail:mengchunxiao@126.com

Shengying Li,E-mail:lishengying@sdu.edu.cn

Xingwang Zhang,E-mail:zhangxingwang@sdu.edu.cn

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Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

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Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

doi: 10.1016/j.apsb.2022.01.013

通讯作者: Chunxiao Meng,E-mail:mengchunxiao@126.com Shengying Li,E-mail:lishengying@sdu.edu.cn Xingwang Zhang,E-mail:zhangxingwang@sdu.edu.cn

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Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction

计量

出版历程

目录

通讯作者:
Chunxiao Meng,E-mail:mengchunxiao@126.com

Shengying Li,E-mail:lishengying@sdu.edu.cn

Xingwang Zhang,E-mail:zhangxingwang@sdu.edu.cn