Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

Yamin Li; Zhongfeng Ye; Hanyi Yang; Qiaobing Xu

doi:10.1016/j.apsb.2022.04.013

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

doi: 10.1016/j.apsb.2022.04.013

a. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA;
b. Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA

基金项目:

This study was supported by the National Institutes of Health (NIH) Grants R01 EB027170-04 and UG3 TR002636-01, USA.

详细信息

通讯作者:
Qiaobing Xu,E-mail:Qiaobing.Xu@tufts.edu

中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383522001861/pdf?md5=5026d16e90253f37cb7b819ebcac905d&pid=1-s2.0-S2211383522001861-main.pdf
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出版历程
- 收稿日期: 2021-12-28
- 修回日期: 2022-03-17
- 录用日期: 2022-04-11
- 网络出版日期: 2023-03-17

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

a. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA;
b. Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA

Funds:

This study was supported by the National Institutes of Health (NIH) Grants R01 EB027170-04 and UG3 TR002636-01, USA.

摘要

摘要: Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of bioactive agents, including the small molecule drugs, proteins and peptides, and nucleic acids. However, as the physicochemical properties of small- and macromolecular cargos can vary drastically, every LNP carrier system needs to be carefully tailored in order to deliver the cargo molecules in a safe and efficient manner. Our group applied the combinatorial library synthesis approach and in vitro and in vivo screening strategy for the development of LNP delivery systems for drug delivery. In this Review, we highlight our recent progress in the design, synthesis, characterization, evaluation, and optimization of combinatorial LNPs with novel structures and properties for the delivery of small- and macromolecular therapeutics both in vitro and in vivo. These delivery systems have enormous potentials for cancer therapy, antimicrobial applications, gene silencing, genome editing, and more. We also discuss the key challenges to the mechanistic study and clinical translation of new LNP-enabled therapeutics.
- Lipid nanoparticle /
- Combinatorial library /
- Drug delivery /
- Cancer therapy /
- Protein delivery /
- Gene therapy
Abstract: Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of bioactive agents, including the small molecule drugs, proteins and peptides, and nucleic acids. However, as the physicochemical properties of small- and macromolecular cargos can vary drastically, every LNP carrier system needs to be carefully tailored in order to deliver the cargo molecules in a safe and efficient manner. Our group applied the combinatorial library synthesis approach and in vitro and in vivo screening strategy for the development of LNP delivery systems for drug delivery. In this Review, we highlight our recent progress in the design, synthesis, characterization, evaluation, and optimization of combinatorial LNPs with novel structures and properties for the delivery of small- and macromolecular therapeutics both in vitro and in vivo. These delivery systems have enormous potentials for cancer therapy, antimicrobial applications, gene silencing, genome editing, and more. We also discuss the key challenges to the mechanistic study and clinical translation of new LNP-enabled therapeutics.
- Lipid nanoparticle /
- Combinatorial library /
- Drug delivery /
- Cancer therapy /
- Protein delivery /
- Gene therapy

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Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

doi: 10.1016/j.apsb.2022.04.013

通讯作者:
Qiaobing Xu,E-mail:Qiaobing.Xu@tufts.edu

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Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

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留言板

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

doi: 10.1016/j.apsb.2022.04.013

通讯作者: Qiaobing Xu,E-mail:Qiaobing.Xu@tufts.edu

计量

出版历程

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

计量

出版历程

目录

通讯作者:
Qiaobing Xu,E-mail:Qiaobing.Xu@tufts.edu