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瘢痕疙瘩中的成纤维细胞特性研究进展

王蕴璋 苏晨 付思祺 刘立强

王蕴璋, 苏晨, 付思祺, 等. 瘢痕疙瘩中的成纤维细胞特性研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(6): 590-594. DOI: 10.3760/cma.j.cn501120-20210510-00176.
引用本文: 王蕴璋, 苏晨, 付思祺, 等. 瘢痕疙瘩中的成纤维细胞特性研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(6): 590-594. DOI: 10.3760/cma.j.cn501120-20210510-00176.
Wang YZ,Su C,Fu SQ,et al.Research advances on the characteristics of fibroblast in keloid[J].Chin J Burns Wounds,2022,38(6):590-594.DOI: 10.3760/cma.j.cn501120-20210510-00176.
Citation: Wang YZ,Su C,Fu SQ,et al.Research advances on the characteristics of fibroblast in keloid[J].Chin J Burns Wounds,2022,38(6):590-594.DOI: 10.3760/cma.j.cn501120-20210510-00176.

瘢痕疙瘩中的成纤维细胞特性研究进展

doi: 10.3760/cma.j.cn501120-20210510-00176
详细信息
    通讯作者:

    刘立强,Email:liuliqiang@psh.pumc.edu.cn

Research advances on the characteristics of fibroblast in keloid

More Information
    Corresponding author: Liu Liqiang, Email: liuliqiang@psh.pumc.edu.cn
  • 摘要: 近20年来,细胞生物学技术的发展推动了瘢痕疙瘩的相关研究。瘢痕疙瘩成纤维细胞(KFb)是瘢痕疙瘩中的主要效应细胞,与瘢痕疙瘩的发生发展密切相关。KFb在生物学特性、基因表达等方面与正常成纤维细胞有明显差异。该文从多个角度对KFb的特性进行了综述,详细描述了其生物学特性如显微结构、代谢特点、增殖性质等情况,并介绍了KFb的异质性与基因组学等方面的主要特征。对KFb研究的不断深入将有助于阐明瘢痕疙瘩的发病机制并为瘢痕疙瘩的防治提供宝贵策略。

     

  • 表1  13篇文献的瘢痕疙瘩成纤维细胞微阵列芯片研究结果

    第1作者年份类别微阵列芯片分析
    Hsu52018基因345种基因↑,86种基因↓
    Inui382011基因374种基因↑,758种基因↓
    Wong392014基因250种基因差异表达
    Satish402006基因43种基因↑,5种基因↓
    Seifert312008基因97种基因↑,26种基因↓
    Hahn412013基因12种基因↑,13种基因↓
    Li422016基因196种基因↑,462种基因↓
    郭晓瑞432011miR1种miR↑,11种miR↓
    Wu352014miR3种miR↑,14种miR↓
    Wu442019miR63种miR↑,76种miR↓
    Yan452020miR14种miR↑,15种miR↓
    Liang462015lncRNA1 731种lncRNA↑,782种lncRNA↓
    Guo472016lncRNA1 290种lncRNA↑,778种lncRNA↓
    注:miR为微小RNA, lncRNA为长链非编码RNA;↑表示上调,↓表示下调
    下载: 导出CSV

      《中华烧伤与创面修复杂志》第六届编辑委员会通讯编委名单按姓氏拼音排序

    贲道锋卞徽宁曹永倩晁生武陈辉陈婧陈朗陈铭锐陈鹏陈晓东
    陈忠勇程君涛迟云飞储国平党永明邓呈亮狄海萍丁国兵丁若虹董茂龙
    段红杰段鹏樊东力房贺冯光付忠华郭毅斌韩兆峰侯春胜胡德林
    胡炯宇胡骁骅胡晓燕黄红军纪世召江华姜丽萍姜玉峰雷娜黎宁
    李东杰李峰李靖李晓东李晓鲁梁钢梁鹏飞林才林国安林源
    刘德伍刘健刘军刘淑华龙奕卢长虹鲁峰吕开阳吕强马思远
    牛轶雯欧阳军乔亮覃凤均邱学文曲滨任超沈江涌石继红宋慧锋
    苏海涛苏永涛孙勇孙瑜谭江琳唐修俊滕苗田社民涂家金汪虹
    汪洋王爱萍王德怀王洪涛王会军王良喜王爽王献珍王志永温冰
    邬佳敏吴红吴继炎吴巍巍吴祖煌向飞向军谢举临谢松涛辛海明
    许喜生许学文薛斌杨建民杨敏烈杨薛康姚明姚兴伟叶祥柏易成刚
    易南于东宁岳丽青翟红军詹日兴张博张东霞张红艳张菊芳张玲娟
    张庆红张彦琦张寅张元海张志赵全赵冉赵雄郑德义郑东风
    郑军周国富周俊峄周琴周万芳朱峰朱宇刚祝筱梅邹立津邹晓防
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-05-10
  • 网络出版日期:  2022-08-12
  • 刊出日期:  2022-06-20

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