Coordinated motion of molecular motors on DNA chains with branch topology

Lu Di; Chen Bin

doi:10.1007/s10409-021-09045-x

Volume 38 Issue 3

Feb 2022

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JOURNAL OF MECHANICAL ENGINEERING > 2022 > 38(3): 621225.

D. Lu, and B. Chen,Coordinated motion of molecular motors on DNA chains with branch topology. Acta Mech. Sin., 2022, 38, http://www.w3.org/1999/xlink' xlink:href='https://doi.org/10.1007/s10409-021-09045-x'>https://doi.org/10.1007/s10409-021-09045-x

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D. Lu, and B. Chen,Coordinated motion of molecular motors on DNA chains with branch topology. Acta Mech. Sin., 2022, 38, http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1007/s10409-021-09045-x">https://doi.org/10.1007/s10409-021-09045-x

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Coordinated motion of molecular motors on DNA chains with branch topology

doi: 10.1007/s10409-021-09045-x

Lu Di¹,
Chen Bin^{1, 2,*
,
,}

1.
Department of Engineering Mechanics, Zhejiang University, Hangzhou 310058, China
2.
Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Hangzhou 310027, China

Funds:

the National Natural Science Foundation of China Grant

More Information

Corresponding author: Chen Bin, E-mail address: chenb6@zju.edu.cn (Bin Chen)
Accepted Date: 25 Jun 2021

Available Online: 01 Aug 2022

Publish Date: 16 Feb 2022
Issue Publish Date: 01 Mar 2022

Abstract

Abstract

To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK_C on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK_C motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsK_C motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsK_C motors. We further suggest the potential application of motors of FtsK_C, together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.
- DNA,
- Molecular motor,
- Coordinated motion,
- Branch topology,
- Strain sensor

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References

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Coordinated motion of molecular motors on DNA chains with branch topology

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