Volume 38 Issue 3
Feb 2022
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JOURNAL OF MECHANICAL ENGINEERING  > 2022  >  38(3): 621569.
Y. Wang, C. Li, H. Dong, J. Yu, Y. Yan, X. Wu, Y. Wang, P. Li, X. Wei, and W. Chen,Mechanosensation of osteocyte with collagen hillocks and primary cilia under pressure and electric field stimulation. Acta Mech. Sin., 2022, 38, http://www.w3.org/1999/xlink' xlink:href='https://doi.org/10.1007/s10409-022-09004-x'>https://doi.org/10.1007/s10409-022-09004-x
Citation: Y. Wang, C. Li, H. Dong, J. Yu, Y. Yan, X. Wu, Y. Wang, P. Li, X. Wei, and W. Chen,Mechanosensation of osteocyte with collagen hillocks and primary cilia under pressure and electric field stimulation. Acta Mech. Sin., 2022, 38, http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1007/s10409-022-09004-x">https://doi.org/10.1007/s10409-022-09004-x
shu

Mechanosensation of osteocyte with collagen hillocks and primary cilia under pressure and electric field stimulation

doi: 10.1007/s10409-022-09004-x
  • 1.

    College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

  • 2.

    Shanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury, Taiyuan 030001, China

Funds:

the National Natural Science Foundation of China Grant

and China Postdoctoral Science Foundation Grant

More Information
    Abstract
  • Mechanosensors are the most important organelles for osteocytes to perceive the changes of surrounding mechanical environment. To evaluate the biomechanical effectiveness of collagen hillock, cell process and primary cilium in lacunar-canalicular system (LCS), we developed pressure-electricity-structure interaction models by using the COMSOL Multiphysics software to characterize the deformation of collagen hillocks- and primary cilium-based mechanosensors in osteocyte under fluid flow and electric field stimulation. And mechanical signals (pore pressure, fluid velocity, stress, deformation) were analyzed in LCS. The effects of changes in the elastic modulus of collagen hillocks, the number and location of cell processes, the length and location of primary cilia on the mechanosensitivity and the overall poroelastic responses of osteocytes were studied. These models predict that the presence of primary cilium and collagen hillocks resulted in significant stress amplifications (one and two orders of magnitude larger than osteocyte body) on the osteocyte. The growth of cell process along the long axis could stimulate osteocyte to a higher level than along the short axis. The Mises stress of the basal body of primary cilia near the top of osteocyte is 8 Pa greater than that near the bottom. However, the presence of collagen hillocks and primary cilium does not affect the mechanical signal of the whole osteocyte body. The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level.

     

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