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JOURNAL OF MECHANICAL ENGINEERING  > 2020  >  33(3): 376-384.
Shan Lei, Li-an Wang, Fu-xing Lin, Kun Zeng, Mo-zhen Wang, Mo-zhen Wang. Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms[J]. JOURNAL OF MECHANICAL ENGINEERING, 2020, 33(3): 376-384. doi: 10.1063/1674-0068/cjcp1906123
Citation: Shan Lei, Li-an Wang, Fu-xing Lin, Kun Zeng, Mo-zhen Wang, Mo-zhen Wang. Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms[J]. JOURNAL OF MECHANICAL ENGINEERING, 2020, 33(3): 376-384. doi: 10.1063/1674-0068/cjcp1906123
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Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms

doi: 10.1063/1674-0068/cjcp1906123
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  • Corresponding author: Fu-xing Lin, E-mail:20180105@fjsmu.edu.cn Tel: +86-598-8397900; Mo-zhen Wang, E-mail: pstwmz@ustc.edu.cn Tel: +86-551-63600843
  • Received Date: 28 Jun 2019
  • Accepted Date: 16 Aug 2019
  • Publish Date: 17 Mar 2020
    Abstract
  • Smart nanoparticles that respond to pathophysiological parameters, such as pH, GSH, and H$ _2 $O$ _2 $, have been developed with the huge and urgent demand for the high-efficient drug delivery systems (DDS) for cancer therapy. Herein, cubic poly(ethylene glycol) (PEG)-modified mesoporous amorphous iron oxide (AFe) nanoparticles (AFe-PEG) have been successfully prepared as pH-stimulated drug carriers, which can combine doxorubicin (DOX) with a high loading capacity of 948 mg/g, forming a novel multifunctional AFe-PEG/DOX nanoparticulate DDS. In an acidic microenvironment, the AFe-PEG/DOX nanoparticles will not only release DOX efficiently, but also release Fe ions to catalyze the transformation of H$ _2 $O$ _2 $ to $ \cdot $OH, acting as fenton reagents. In vitro experimental results proved that the AFe-PEG/DOX nanoparticles can achieve combination of chemotherapeutic (CTT) and chemodynamic therapeutic (CDT) effects on Hela tumor cells. Furthermore, the intrinsic magnetism of AFe-PEG/DOX makes its cellular internalization efficiency be improved under an external magnetic field. Therefore, this work develops a new and promising magnetically targeted delivery and dual CTT/CDT therapeutic nano-medicine platform based on amorphous iron oxide.

     

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