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JOURNAL OF MECHANICAL ENGINEERING  > 2021  >  12(5): 705-712.
REN Jing, HE Yonglan, LI Yuan, CAO Ying, XIA Chen, XIANG Yang, XUE Huadan, JIN Zhengyu. The Value of Model Based on Radiomics Features of T2-weighted Imaging and Clinical Feature in Diagnosing the Depth of Stromal Invasion of Cervical Squamous Cell Carcinoma[J]. JOURNAL OF MECHANICAL ENGINEERING, 2021, 12(5): 705-712. doi: 10.12290/xhyxzz.2021-0437
Citation: REN Jing, HE Yonglan, LI Yuan, CAO Ying, XIA Chen, XIANG Yang, XUE Huadan, JIN Zhengyu. The Value of Model Based on Radiomics Features of T2-weighted Imaging and Clinical Feature in Diagnosing the Depth of Stromal Invasion of Cervical Squamous Cell Carcinoma[J]. JOURNAL OF MECHANICAL ENGINEERING, 2021, 12(5): 705-712. doi: 10.12290/xhyxzz.2021-0437
shu

The Value of Model Based on Radiomics Features of T2-weighted Imaging and Clinical Feature in Diagnosing the Depth of Stromal Invasion of Cervical Squamous Cell Carcinoma

doi: 10.12290/xhyxzz.2021-0437
Funds:

National Natural Science Foundation of China 81901829

Fundamental Research Funds for Central Universities of Peking Union Medical College 3332019032

More Information
  • Corresponding author: XIANG Yang  Tel: 86-10-69156218, E-mail: XiangY@pumch.cn; XUE Huadan  Tel: 86-10-69155509, E-mail: bjdanna95@hotmail.com
  • Received Date: 30 May 2021
  • Accepted Date: 04 Aug 2021
    • Available Online: 26 Nov 2021
  • Issue Publish Date: 30 Sep 2021
    Abstract
  •   Objective  To investigate the prediction value of a clinical-radiomics model based on T2- weighted imaging (T2WI) and clinical features for diagnosing deep stromal invasion (DSI) in patients with early-stage cervical squamous cell carcinoma.
      Methods  Patients with early-stage cervical squamous cell carcinoma that underwent radical hysterectomy in Peking Union Medical College Hospital from January 2017 to February 2021 were retrospectively included and randomly divided into the training set and the validation set with the the ratio of 8∶2. The preoperative clinical features and the radiomics features of sagittal T2WI images were obtained. After selection of key features, a radiomics model, a clinical model, and a clinical-radiomics model for diagnosing DSI in early-stage cervical squamous cell carcinoma were developed by Logistic regression based on the training set. The performance of different models was compared by the receiver operating characteristic (ROC) curve in the validation set.
      Results  A total of 168 patients with early-stage cervical squamous cell carcinoma that met the inclusion and exclusion criteria were included in this study. They were randomly divided into the training set (n=135) and the validation set (n=33), in which 72 cases had histopathologically confirmed superficial stromal invasion and 96 cases had DSI. Four radiomics features and three clinical parameters (age, Federation International of Gynecology and Obstetrics stage, and preoperative squamous cell carcinoma antigen levels) were selected and used to develop models. In the validation set, the clinical-radiomics model showed better diagnostic performance with the area under the curve (AUC) of 0.820 (95% CI: 0.665-0.974) than the clinical model[AUC: 0.797(95% CI: 0.623-0.971)] and the radiomics model[AUC: 0.793(95% CI: 0.633-0.954)].The sensitivity, specificity, and accuracy of the clinical-radiomics model were 85.7%(95% CI: 49.8%-100%), 73.7%(95% CI: 57.9%-100%), and 78.8%(95% CI: 69.7%-93.9%), respectively.
      Conclusion  Radiomics features based on T2WI images combined with clinical features can be used as a noninvasive preoperative method to determine the depth of stromal invasion in early-stage cervical squamous cell carcinoma.

     

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    • References(22)
  • [1]
    Small W, JR, Bacon MA, Bajaj A, et al. Cervical cancer: A global health crisis[J]. Cancer, 2017, 123: 2404-2412. doi: 10.1002/cncr.30667
    [2]
    Lu X, Jiang L, Zhang L, et al. Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome[J]. Neoplasia, 2019, 21: 591-601. doi: 10.1016/j.neo.2019.04.003
    [3]
    Sedlis A, Bundy BN, Rotman MZ, et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study[J]. Gynecol Oncol, 1999, 73: 177-183. doi: 10.1006/gyno.1999.5387
    [4]
    National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Cervical Cancer (Version 1.2021)[EB/OL]. (2020-1-14)[2021-8-26]. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1426.
    [5]
    Chino J, Annunziata CM, Beriwal S, et al. Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline[J]. Pract Radiat Oncol, 2020, 10: 220-234. doi: 10.1016/j.prro.2020.04.002
    [6]
    Cibula D, Pötter R, Planchamp F, et al. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer[J]. Radiother Oncol, 2018, 127: 404-416. doi: 10.1016/j.radonc.2018.03.003
    [7]
    Wu Q, Wang S, Chen X, et al. Radiomics analysis of magnetic resonance imaging improves diagnostic performance of lymph node metastasis in patients with cervical cancer[J]. Radiother Oncol, 2019, 138: 141-148. doi: 10.1016/j.radonc.2019.04.035
    [8]
    Xiao M, Ma F, Li Y, et al. Multiparametric MRI-Based Radiomics Nomogram for Predicting Lymph Node Metastasis in Early-Stage Cervical Cancer[J]. J Magn Reson Imaging, 2020, 52: 885-896. doi: 10.1002/jmri.27101
    [9]
    Li Z, Li H, Wang S, et al. MR-Based Radiomics Nomogram of Cervical Cancer in Prediction of the Lymph-Vascular Space Invasion preoperatively[J]. J Magn Reson Imaging, 2019, 49: 1420-1426. doi: 10.1002/jmri.26531
    [10]
    Wu Q, Shi D, Dou S, et al. Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma[J]. J Magn Reson Imaging, 2019, 49: 1141-1148. doi: 10.1002/jmri.26301
    [11]
    Bhatla N, Aoki D, Sharma DN, et al. Cancer of the cervix uteri[J]. Int J Gynecol Obstet, 2018, 143: 22-36. doi: 10.1002/ijgo.12611
    [12]
    Allam M, Feely C, Millan D, et al. Depth of cervical stromal invasion as a prognostic factor after radical surgery for early stage cervical cancer[J]. Gynecol oncol, 2004, 93: 637-641. doi: 10.1016/j.ygyno.2004.02.029
    [13]
    Bhatla N, Berek JS, Cuello Fredes M, et al. Revised FIGO staging for carcinoma of the cervix uteri[J]. Int J Gynaecol Obstet, 2019, 145: 129-135. doi: 10.1002/ijgo.12749
    [14]
    Shu T, Zhao D, Li B, et al. Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer: 10 years' experience of National Cancer Center in China[J]. Chin J Cancer Res, 2017, 29: 510-520. doi: 10.21147/j.issn.1000-9604.2017.06.05
    [15]
    Lakhman Y, Akin O, park KJ, et al. Stage IB1 cervical cancer: role of preoperative MR imaging in selection of patients for fertility-sparing radical trachelectomy[J]. Radiology, 2013, 269: 149-158. doi: 10.1148/radiol.13121746
    [16]
    Landoni F, Colombo A, MIlani R, et al. Randomized study between radical surgery and radiotherapy for the treatment of stage IB-ⅡA cervical cancer: 20-year update[J]. J Gynecol Oncol, 2017, 28: e34. doi: 10.3802/jgo.2017.28.e34
    [17]
    Moloney F, Ryan D, Twomey M, et al. Comparison of MRI and high-resolution transvaginal sonography for the local staging of cervical cancer[J]. J Clin Ultrasound, 2016, 44: 78-84. doi: 10.1002/jcu.22288
    [18]
    朱汇慈, 曹崑, 李晓婷, 等. MRI评估早期宫颈癌间质浸润深度[J]. 中国医学影像技术, 2020, 36: 559-563. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXX202004020.htm

    Zhu HC, Cao K, Li XT, et al. MRI assessment of eary cervical cancer invasion depth of stroma[J]. Zhongguo Yixue Yingxiang Jishu, 2020, 36: 559-563. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXX202004020.htm
    [19]
    Epstein E, Testa A, Gaurilcikas A, et al. Early-stage cervical cancer: tumor delineation by magnetic resonance imaging and ultrasound - a European multicenter trial[J]. Gynecol Oncol, 2013, 128: 449-453. doi: 10.1016/j.ygyno.2012.09.025
    [20]
    Xu D, Wang D, Wang S, et al. Correlation Between Squamous Cell Carcinoma Antigen Level and the Clinicopathological Features of Early-Stage Cervical Squamous Cell Carcinoma and the Predictive Value of Squamous Cell Carcinoma Antigen Combined With Computed Tomography Scan for Lymph Node Metastasis[J]. Int J Gynecol Cancer, 2017, 27: 1935-1942. doi: 10.1097/IGC.0000000000001112
    [21]
    Liu S, Xia L, Yang Z, et al. The feasibility of (18)F-FDG PET/CT for predicting pathologic risk status in early-stage uterine cervical squamous cancer[J]. Cancer Imaging, 2020, 20: 63. doi: 10.1186/s40644-020-00340-z
    [22]
    朱成功, 姜继勇, 张文清, 等. 术前血清鳞状细胞癌抗原水平对早期宫颈鳞癌淋巴结转移的预测价值[J]. 现代妇产科进展, 2020, 29: 896-900. https://www.cnki.com.cn/Article/CJFDTOTAL-XDFC202012004.htm

    Zhu CG, Jiang JY, Zhang WQ, et al. Predictive value of preoperative serum squamous cell carcinoma antigen level for lymph node metastasis of early-stage cervical squamous cell carcinoma[J]. Xiandai Fuchanke Jinzhan, 2020, 29: 896-900. https://www.cnki.com.cn/Article/CJFDTOTAL-XDFC202012004.htm
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