Issue 10
May. 2023
Turn off MathJax
Article Contents
CHEN Shujun, HAO Minquan, ZHANG Lizhen. Alleviating Effect of Millet Products on Diarrhea Induced by Senna Leaf in Mice[J]. Science and Technology of Food Industry, 2023, 44(10): 362−368. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022080022
Citation: CHEN Shujun, HAO Minquan, ZHANG Lizhen. Alleviating Effect of Millet Products on Diarrhea Induced by Senna Leaf in Mice[J]. Science and Technology of Food Industry, 2023, 44(10): 362−368. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022080022

Alleviating Effect of Millet Products on Diarrhea Induced by Senna Leaf in Mice

doi: 10.13386/j.issn1002-0306.2022080022
  • Received Date: 03 Aug 2022
  • Issue Publish Date: 15 May 2023
  • To study the alleviating effect of different millet products on diarrhea caused by senna leaf in mice. Eighty-four KM mice were randomly divided into 7 groups: Normal control group, model group, positive control group, fermented millet group (6.16 g/kg), ferment millet bran group (2.05 g/kg), millet gruel oil group (10.27 g/kg), and millet bran porridge oil group (10.27 g/kg). Senna leaf was used to establish a diarrhea model in mice. After 7 days of modeling, except for the model group, the other groups were treated for 7 days. The diarrhea index, viscera index, serum inflammatory factors, secretory immunoglobulin A (SIgA) levels, and small intestine section observation were used to evaluate the effects of millet products on diarrhea mice. Compared with the model group, the weight of mice in the millet product group increased significantly on the 13th day (P<0.05), the diarrhea index was significantly decreased (P<0.05), the contents of serum inflammatory factors in ferment millet bran group, fermented millet group, and millet porridge oil group were significantly decreased (P<0.05), the content of secreted immunoglobulin A in intestinal mucosa was significantly increased (P<0.05), small intestine tissue section observation integrity was good. Fermented millet bran, fermented millet, and millet porridge oil in millet products could alleviate diarrhea induced by senna leaf in mice, but the therapeutic mechanism and the changes of intestinal flora in them remain to be further explored.

     

  • loading
  • [1]
    景亚凤, 吴玉良, 吴纯洁, 等. 焦米对番泻叶所致腹泻小鼠的止泻及肠道菌群影响研究[J]. 中国微生态学杂志,2012,24(4):321−323. [JING Y F, WU Y L, WU C J, et al. Antidiarrhea effect of cooked rice and its influence on intestinal tract bacteria in mice with senna leaf resulted diarrhea[J]. Chinese Journal of Microecology,2012,24(4):321−323. doi: 10.13381/j.cnki.cjm.2012.04.010
    [2]
    郑鹏飞. 大黄炭的止泻作用及其物质基础研究[D]. 北京: 北京中医药大学, 2018.

    ZHENG P F. Study on antidiarrheal effect and material basis of Rhubarb charcoal[D]. Beijing: Beijing University of Chinese Medicine, 2018.
    [3]
    DYKES L, ROONEY L W. Phenolic compounds in cereal grains and their health benefits[J]. Cereal Foods World,2008,52(3):105−111.
    [4]
    YADAV N, CHAUDHARY K, SINGH A, et al. Evaluation of hypoglycemic properties of kodo millet based food products in healthy subjects[J]. IOSR Journal of Pharmacy,2013,3(2):14−20.
    [5]
    VISWANATH V, UROOJ A, MALLESHI N G. Evaluation of antioxidant and antimicrobial properties of finger millet polyphenols (Eleusine coracana)[J]. Food Chemistry,2008,114(1):340−346.
    [6]
    AMIR G, ROMEE J, GULZAR A, et al. Significance of finger millet in nutrition, health and value added products: A review[J]. Journal of Environmental Science, Computer Science and Engineering & Technology,2014,3(3):1601−1608.
    [7]
    郑向华, 叶宁, 洪春燕, 等. 米汤的营养保健功能[J]. 福建稻麦科技,2011,29(3):77−79. [ZHENG X H, YE N, HONG C Y, et al. Health and nutrition function of rice water[J]. Fujian Rice and Wheat Science and Technology,2011,29(3):77−79. doi: 10.3969/j.issn.1008-9799.2011.03.035
    [8]
    曾蓁, 杨丽萍, 胡瑶, 等. 米汤止泻作用及其机制[J]. 医药导报,2015,34(2):170−173. [ZENG Z, YANG L P, HU Y, et al. Antidiarrheal effect of rice soup and related mechanism[J]. Chinese Journal of Medicine,2015,34(2):170−173. doi: 10.3870/yydb.2015.02.008
    [9]
    陈树俊, 郭琪, 杨宝. 小米粥油制备及抑菌和吸附内毒素作用的研究[J]. 中国粮油学报,2021,36(2):102−108. [CHEN S J, GUO Q, YANG B. Preparation of millet porridge oil and its antibacterial and endotoxin adsorption effects[J]. Journal of the Chinese Cereals and Oils Association,2021,36(2):102−108. doi: 10.3969/j.issn.1003-0174.2021.02.017
    [10]
    NDUTI N, MCMILLAN A, SENEY S, et al. Investigating probiotic yoghurt to reduce an aflatoxin B1 biomarker among school children in Eastern Kenya: Preliminary study[J]. International Dairy Journal,2016,63:124−129. doi: 10.1016/j.idairyj.2016.07.014
    [11]
    YANG X D, ERICA T, LI G H, et al. High protective efficacy of rice bran against human rotavirus diarrhea via enhancing probiotic growth, gut barrier function, and innate immunity[J]. Scientific Reports,2015,5:15004. doi: 10.1038/srep15004
    [12]
    VICKI L, HENRIK F, KIM F M. Spontaneously fermented millet product as a natural probiotic treatment for diarrhoea in young children: An intervention study in Northern Ghana[J]. International Journal of Food Microbiology,2006,110(3):246−253. doi: 10.1016/j.ijfoodmicro.2006.04.022
    [13]
    ISLAM J, KOSEKI T, WATANABE K, et al. Dietary supplementation of fermented rice bran effectively alleviates dextran sodium sulfate-induced colitis in mice[J]. Nutrients,2017,9(7):747. doi: 10.3390/nu9070747
    [14]
    ALAUDDIN M, SHIRAKAWA H, KOSEKI T, et al. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats[J]. BMC Complement Altern Med,2016,16(1):442. doi: 10.1186/s12906-016-1427-z
    [15]
    AZIMIRAD M, ALEBOUYEH M, NAJI T. Inhibition of lipopolysaccharide-induced interleukin 8 in human adenocarcinoma cell line HT-29 by spore probiotics: B. coagulans and B. subtilis (natto)[J]. Probiotics & Antimicrobial Proteins, 2017, 9(1): 56-63.
    [16]
    赵会利, 曹玉凤, 高艳霞, 等. 纳豆芽孢杆菌对断奶犊牛生长性能和血液生化指标的影响[J]. 中国畜牧杂志,2013,49(17):66−69. [ZHAO H L, CAO T F, GAO Y X, et al. Effects of Bacillus natto on growth performance and blood biochemical indices of weaned calves[J]. Chinese Journal of Animal Science,2013,49(17):66−69. doi: 10.3969/j.issn.0258-7033.2013.17.016
    [17]
    ISLAM J, SATO S, WATANABE K, et al. Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice[J]. The Journal of Nutritional Biochemistry,2017,42:43−50. doi: 10.1016/j.jnutbio.2016.12.019
    [18]
    陈秋三, 夏宝莹, 韦建缘, 等. 番泻叶对小鼠粪便的影响[J]. 世界最新医学信息文摘,2018,18(2):86−87,174. [CHEN Q S, XIA B Y, WEI J Y, et al. Effects of senna leaves on feces in mice[J]. World Latest Medical Information,2018,18(2):86−87,174. doi: 10.19613/j.cnki.1671-3141.2018.02.065
    [19]
    周干南, 胡芝华, 汪亚先, 等. 小鼠腹泻模型的制备与腹泻指数的应用[J]. 中草药,1994,25(4):195−196,199,223−224. [ZHOU G N, HU Z H, WANG Y X, et al. An inquiry into preparing diarrhea model of mice and application of diarrhea index[J]. Chinese Traditional and Herbal Medicines,1994,25(4):195−196,199,223−224.
    [20]
    王雪, 张圣方, 赵龙玉, 等. 长根菇多糖对小鼠肠道菌群及分泌型IgA的影响[J]. 食品工业科技,2015,36(13):376−379,384. [WANG X, ZHANG S F, ZHAO Y L, et al. Effect of Collybia radiata polysaccharides on intestinal flora and secretory immunoglobulin A in mice[J]. Science and Technology of Food Industry,2015,36(13):376−379,384. doi: 10.13386/j.issn1002-0306.2015.13.071
    [21]
    吴蕊, 余新超. 苦参提取液对肠致病性大肠杆菌感染小鼠的疗效研究[J]. 现代医药卫生,2015,31(5):665−667. [WU X, YU X C. Curative effect of sophora flavescens extraction in treatment of enteropathogenic E. coli of infected mice[J]. Modern Medical Health,2015,31(5):665−667. doi: 10.3969/j.issn.1009-5519.2015.05.010
    [22]
    JAHIDUL I, AFIFIFAH Z A, KOUICHI W, et al. Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice[J]. The Journal of Nutritional Biochemistry,2021,99:108855.
    [23]
    AGISTA A Z, RUSBANA T B, ISLAMJ, et al. Fermented rice bran supplementation prevents the development of intestinal fibrosis due to DSS-Induced inflammation in mice[J]. Nutrients,2021,13(6):1869. doi: 10.3390/nu13061869
    [24]
    王广. 党参多糖对肠道菌群失调小鼠的调整作用机制的初步研究[D]. 佳木斯: 佳木斯大学, 2010.

    WANG G. Preliminary study on the regulatory mechanism of Codonopsis pilosula polysaccharide on intestinal microflora disorder mice[D]. Jiamusi: Jiamusi University, 2010.
    [25]
    HAN B, LIU Y H, QIU Z Q, et al. Secretory immunoglobulin A and intestinal diseases[J]. Shijie Huaren Xiaohua Zazhi,2017,25(19):1757−1763.
    [26]
    孙博云, 王师英, 胡鸿毅. 肠黏膜通透性改变与炎症性肠病关系的研究进展[J]. 中国中西医结合消化杂志,2016,24(11):891−894. [SUN B Y, WANG S Y, HU H Y. Research progress on the relationship between intestinal permeability changes and inflammatory bowel disease[J]. Chinese Journal of Integrated Traditional and Western Medicine Digestion,2016,24(11):891−894.
    [27]
    ZHOU L, IVANOV I I, SPOLSKI R, et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways[J]. Nature Immunology,2007,8:967−974. doi: 10.1038/ni1488
    [28]
    HUNTER C A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions[J]. Nature Reviews Immunology,2005,5:521−531. doi: 10.1038/nri1648
    [29]
    KOMIYAMA Y, ANDOH A, FUJIWARA D, et al. New prebiotics from rice bran ameliorate inflflammation in murine colitis models through the modulation of intestinal homeostasis and the mucosal immune system[J]. Scand J Gastroenterol,2011,46:40−52. doi: 10.3109/00365521.2010.513062
    [30]
    王菁. 不同种类及剂量全谷物对糖脂代谢及相关机制的研究[D]. 南京: 东南大学, 2019

    WANG J. Study on different kinds and doses of whole grains on glucolipid metabolism and its mechanism[D]. Nanjing: Southeast University, 2019.
    [31]
    陈博睿, 付永霞, 侯殿志, 等. 不同摄入量小米对小鼠肠道菌群和短链脂肪酸的影响[J]. 食品科学技术学报,2022,40(3):56−67. [CHEN B R, FU Y X, HOU D Z, et al. Effects of different foxtail millet intake on gut microbiota and short chain fatty acids in mice[J]. Journal of Food Science and Technology,2022,40(3):56−67. doi: 10.12301/spxb202100871
    [32]
    HONDA K, LITTMAN D R. The microbiota in adaptive immune homeostasis and disease[J]. Nature,2016,535:75−84. doi: 10.1038/nature18848
    [33]
    RYAN E P. Bioactive food components and health properties of rice bran[J]. J Am Vet Med Assoc,2011,238:593−600. doi: 10.2460/javma.238.5.593
    [34]
    于健康. 复方白头翁散对小鼠的止泻作用研究[D]. 雅安: 四川农业大学, 2018.

    YU J K. Study on antidiarrheal effect of Compound Baitouweng Powder on mice[D]. Yaan: Sichuan Agricultural University, 2018.
    [35]
    GUO L, SUN Y L, WANG A H, et al. Effect of polysaccharides extract of Rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats[J]. Molecular Biology Reports,2012,39(10):9285−9290. doi: 10.1007/s11033-012-1677-x
    [36]
    ANGELA J H, STEVEN W D, ELIZABETH P R, et al. Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp[J]. Journal of Medicinal Food,2012,15(5):469−475. doi: 10.1089/jmf.2011.0213
    [37]
    林莹, 杨军红, 陈颖新, 等. 米油对急性腹泻患儿大便分泌型免疫球蛋白A含量及疾病转归的影响[J]. 中华临床营养杂志,2015,23(4):214−218. [LIN Y, YANG J H, CHEN Y X, et al. Effect of millet oil on fecal secreted immunoglobulin A content and disease outcome in children with acute diarrhea[J]. Chinese Journal of Clinical Nutrition,2015,23(4):214−218. doi: 10.3760/cma.j.issn.1674-635X.2015.04.004
  • 加载中

Catalog

    Figures(5)  / Tables(2)

    Article Metrics

    Article views(22) PDF downloads(0) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return