Preparation and Stability of Nanostructured Lipid Carriers of Phytosterols with Walnut Oil

HUAI Qitong; LIU Lin; ZHANG Jiaxin; SUN Mengyuan; CHANG Chengfu; SUN Zhengyin; ZHANG Fengkai; LI Dan; ZHENG Huanyu

doi:10.13386/j.issn1002-0306.2022100279

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May. 2023

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JOURNAL OF MECHANICAL ENGINEERING > 2023 > 44(9): 38-44.

HUAI Qitong, LIU Lin, ZHANG Jiaxin, et al. Preparation and Stability of Nanostructured Lipid Carriers of Phytosterols with Walnut Oil[J]. Science and Technology of Food Industry, 2023, 44(9): 38−44. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022100279

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Preparation and Stability of Nanostructured Lipid Carriers of Phytosterols with Walnut Oil

doi: 10.13386/j.issn1002-0306.2022100279

HUAI Qitong^1
,,
LIU Lin²,
ZHANG Jiaxin¹,
SUN Mengyuan¹,
CHANG Chengfu¹,
SUN Zhengyin¹,
ZHANG Fengkai¹,
LI Dan^{2, 3,*
,
,},
ZHENG Huanyu^{1, 2, 3,*
,
,}

1.
College of Food Science, Northeast Agricultural University, Harbin 150030, China
2.
Heilongjiang Green Food Science Research Institute, Harbin 150028, China
3.
National Research Center of Soybean Engineering and Technology, Harbin 150028, China

Received Date: 01 Nov 2022
Issue Publish Date: 01 May 2023

Abstract

Abstract

Nanostructured lipid carriers (NLC) for the encapsulation and protection of phytosterol (PS) were prepared using walnut oil as liquid lipid by high-pressure homogenization method. The average particle size, polydispersity index, Zeta potential and encapsulation efficiency were used as the main evaluation indexes to optimize the preparation process parameters and formulations, and the morphology and stability of the optimized PS-NLC were investigated. The optimal ratio for the preparation of PS-NLC was determined by orthogonal tests as 10% of total lipid concentration, 2:3 of stearic acid and walnut oil, and 1.2% of soy lecithin. The prepared PS-NLC had a spherical appearance, small particle size and uniform distribution. The stability results of PS-NLC showed that PS-NLC was stable in storage at 4 ℃ for 28 days. It was diluted 5~100 times with good dilution stability, when used. And the addition of 2% sucrose had the best effect on the lyophilization protection of PS-NLC. Walnut oil was used as the wall material of NLC to provide a suitable lipid delivery system for phytosterols, which could provide technical support for the construction of PS-NLC in food industry.
- phytosterol,
- nanostructured lipid carriers,
- walnut oil,
- soy lecithin,
- stearic acid

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References

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Preparation and Stability of Nanostructured Lipid Carriers of Phytosterols with Walnut Oil

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