Research advances of the roles of sphingosine-1-phosphate in acute lung injury

Wang Mengyan; Cui Pei; Xin Haiming

doi:10.3760/cma.j.cn501120-20210703-00234

Issue 5

Jul 2022

Turn off MathJax

Article Contents

JOURNAL OF MECHANICAL ENGINEERING > 2022 > 38(5): 496-500.

Wang MY,Cui P,Xin HM.Research advances of the roles of sphingosine-1-phosphate in acute lung injury[J].Chin J Burns Wounds,2022,38(5):496-500.DOI: 10.3760/cma.j.cn501120-20210703-00234.

Citation:

Wang MY,Cui P,Xin HM.Research advances of the roles of sphingosine-1-phosphate in acute lung injury[J].Chin J Burns Wounds,2022,38(5):496-500.DOI: 10.3760/cma.j.cn501120-20210703-00234.

Citation:

Wang MY,Cui P,Xin HM.Research advances of the roles of sphingosine-1-phosphate in acute lung injury[J].Chin J Burns Wounds,2022,38(5):496-500.DOI: 10.3760/cma.j.cn501120-20210703-00234.

PDF( 462 KB)

Research advances of the roles of sphingosine-1-phosphate in acute lung injury

doi: 10.3760/cma.j.cn501120-20210703-00234

Wang Mengyan^{1, 2},
Cui Pei²,
Xin Haiming^{2,
,
,}

1.
College of Life Sciences, Guangxi Normal University, Guilin 541002, China
2.
Lung Injury Group of Guangxi Key Laboratory of Metabolic Diseases, Department of Burns and Plastic Surgery, the 924th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Guilin 541002, China

Funds:

Guangxi Science and Technology Base and Talent Special Program AD18126016

Science and Technology Planning Program of Guilin 20170109-35

Special Fund of Lijiang Scholars

Science and Technology Program of the 924th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army GS2020CZ06, GS2020FH08

More Information

Corresponding author: Xin Haiming, Email: xinhm123@163.com
Received Date: 03 Jul 2021
Available Online: 20 Jul 2022
Issue Publish Date: 20 May 2022

Abstract

Abstract

Sphingosine-1-phosphate (S1P) is the main metabolite produced in the process of phospholipid metabolism, which can promote proliferation, migration, and apoptosis of cells, and maintain the barrier function of vascular endothelium. The latest researches showed that S1P can alleviate acute lung injury (ALI) and the inflammation caused by ALI, while the dosage of S1P is still needed to be considered. Mesenchymal stem cells (MSCs) have been a emerging therapy with potential therapeutic effects on ALI because of their characteristics of self-replication and multi-directional differentiation, and their advantages in hematopoiesis, immune regulation, and tissue repair. S1P can promote differentiation of MSCs and participate in immune regulation, while MSCs can regulate the homeostasis of S1P in the body. The synergistic effect of S1P and MSC provides a new treatment method for ALI. This article reviews the production and biological function of S1P, receptor and signal pathway of S1P, the therapeutic effects of S1P on ALI, and the research advances of S1P combined with MSCs in the treatment of ALI, aiming to provide theoretical references for the development of S1P targeted drugs in the treatment of ALI and the search for new combined treatment schemes for ALI.
- Acute lung injury,
- Mesenchymal stem cells,
- Sphingosine-1-phosphate,
- Biological function

FullText(HTML)

References(44)

References

[1]	MokraD,KosutovaP.Biomarkers in acute lung injury[J].Respir Physiol Neurobiol,2015,209:52-58.DOI: 10.1016/j.resp.2014.10.006.
[2]	CombesA,PesentiA,RanieriVM.Fifty years of research in ARDS. Is extracorporeal circulation the future of acute respiratory distress syndrome management?[J].Am J Respir Crit Care Med,2017,195(9):1161-1170.DOI: 10.1164/rccm.201701-0217CP.
[3]	俞正秋,马春芳,蔡宛如.急性肺损伤/急性呼吸窘迫综合征治疗进展[J].中国现代医生,2021,59(13):189-192.
[4]	NoonePM,ReddySP.Recent advances in dead cell clearance during acute lung injury and repair[J].Fac Rev,2021,10:33.DOI: 10.12703/r/10-33.
[5]	FanY,ChenJ,LiuD,et al.HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro[J].Int J Biochem Cell Biol,2020,126:105819.DOI: 10.1016/j.biocel.2020.105819.
[6]	BehnkeJ,KremerS,ShahzadT,et al.MSC based therapies-new perspectives for the injured lung[J].J Clin Med,2020,9(3):682.DOI: 10.3390/jcm9030682.
[7]	LuW,XiuX,ZhaoY,et al.Improved proliferation and differentiation of bone marrow mesenchymal stem cells into vascular endothelial cells with sphingosine 1-phosphate[J].Transplant Proc,2015,47(6):2035-2040.DOI: 10.1016/j.transproceed.2015.05.032.
[8]	张淼补肾化痰法经Sphk1/S1P-PI3K/AKT/CyclinD1信号通路调控肥胖PCOS模型雌鼠子宫内膜容受性机制研究成都成都中医药大学2019 张淼. 补肾化痰法经Sphk1/S1P-PI3K/AKT/CyclinD1信号通路调控肥胖PCOS模型雌鼠子宫内膜容受性机制研究[D]. 成都:成都中医药大学, 2019.
[9]	LidgerwoodGE,PitsonSM,BonderC,et al.Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology[J].Prog Lipid Res,2018,72:42-54.DOI: 10.1016/j.plipres.2018.09.001.
[10]	XiongY,HlaT.S1P control of endothelial integrity[J].Curr Top Microbiol Immunol,2014,378:85-105.DOI: 10.1007/978-3-319-05879-5_4.
[11]	HopsonKP,TrueloveJ,ChunJ,et al.S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells[J].Am J Physiol Cell Physiol,2011,300(4):C919-926.DOI: 10.1152/ajpcell.00350.2010.
[12]	ProiaRL,HlaT.Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy[J].J Clin Invest,2015,125(4):1379-1387.DOI: 10.1172/JCI76369.
[13]	YaoX,XieL,ZengY.MiR-9 Promotes angiogenesis via targeting on sphingosine-1-phosphate receptor 1[J].Front Cell Dev Biol,2020,8:755.DOI: 10.3389/fcell.2020.00755.
[14]	FanX,LiuL,ShiY,et al.Recent advances of the function of sphingosine 1-phosphate (S1P) receptor S1P3[J].J Cell Physiol,2021,236(3):1564-1578.DOI: 10.1002/jcp.29958.
[15]	BaeyensA,SchwabSR.Finding a way out: S1P signaling and immune cell migration[J].Annu Rev Immunol,2020,38:759-784.DOI: 10.1146/annurev-immunol-081519-083952.
[16]	MagayeRR,SaviraF,HuaY,et al.Attenuating PI3K/Akt-mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells[J].Int J Biochem Cell Biol,2021,134:105952.DOI: 10.1016/j.biocel.2021.105952.
[17]	ParkJH,ParkKK,ChoeJY,et al.Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells[J].Ann Pediatr Endocrinol Metab,2021,26(4):252-258.DOI: 10.6065/apem.2040266.133.
[18]	CastaldiA,ChesiniGP,TaylorAE,et al.Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs[J].Cell Signal,2016,28(8):871-879.DOI: 10.1016/j.cellsig.2016.04.006.
[19]	ShiW,MaD,CaoY,et al.SphK2/S1P promotes metastasis of triple-negative breast cancer through the PAK1/LIMK1/Cofilin1 signaling pathway[J].Front Mol Biosci,2021,8:598218.DOI: 10.3389/fmolb.2021.598218.
[20]	TsaiHC,HanMH.Sphingosine-1-phosphate (S1P) and S1P signaling pathway: therapeutic targets in autoimmunity and inflammation[J].Drugs,2016,76(11):1067-1079.DOI: 10.1007/s40265-016-0603-2.
[21]	YuH.Targeting S1PRs as a therapeutic strategy for inflammatory bone loss diseases-beyond regulating S1P signaling[J].Int J Mol Sci,2021,22(9):4411.DOI: 10.3390/ijms22094411.
[22]	HarijithA,PendyalaS,EbenezerDL,et al.Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium[J].Am J Physiol Lung Cell Mol Physiol,2016,311(2):L337-351.DOI: 10.1152/ajplung.00447.2015.
[23]	HaAW,BaiT,EbenezerDL,et al.Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury[J].Thorax,2022,77(1):47-57.DOI: 10.1136/thoraxjnl-2020-216469.
[24]	ZhaoJ,LiuJ,LeeJF,et al.TGF-β/SMAD3 pathway stimulates sphingosine-1 phosphate receptor 3 expression: implication of sphingosine-1 phosphate receptor 3 in lung adenocarcinoma progression[J].J Biol Chem,2016,291(53):27343-27353.DOI: 10.1074/jbc.M116.740084.
[25]	PunsawadC,ViriyavejakulP.Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model[J].PLoS One,2019,14(9):e0222098.DOI: 10.1371/journal.pone.0222098.
[26]	KnipeRS,SpinneyJJ,AbeEA,et al.Endothelial-specific loss of sphingosine-1-phosphate receptor 1 increases vascular permeability and exacerbates bleomycin-induced pulmonary fibrosis[J].Am J Respir Cell Mol Biol,2022,66(1):38-52.DOI: 10.1165/rcmb.2020-0408OC.
[27]	HuangLS,BerdyshevE,MathewB,et al.Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis[J].FASEB J,2013,27(4):1749-1760.DOI: 10.1096/fj.12-219634.
[28]	HuangLS,SudhadeviT,FuP,et al.Sphingosine kinase 1/S1P signaling contributes to pulmonary fibrosis by activating Hippo/YAP pathway and mitochondrial reactive oxygen species in lung fibroblasts[J].Int J Mol Sci,2020,21(6):2064.DOI: 10.3390/ijms21062064.
[29]	DonatiC,CencettiF,BernacchioniC,et al.Role of sphingosine 1-phosphate signalling in tissue fibrosis[J].Cell Signal,2021,78:109861.DOI: 10.1016/j.cellsig.2020.109861.
[30]	GutbierB,SchönrockSM,EhrlerC,et al.Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the sphingosine-1-phosphate receptor 2[J].Crit Care Med,2018,46(3):e258-e267.DOI: 10.1097/CCM.0000000000002916.
[31]	SheaBS,BrooksSF,FontaineBA,et al.Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury[J].Am J Respir Cell Mol Biol,2010,43(6):662-673.DOI: 10.1165/rcmb.2009-0345OC.
[32]	ZhaoY,GorshkovaIA,BerdyshevE,et al.Protection of LPS-induced murine acute lung injury by sphingosine-1- phosphate lyase suppression[J].Am J Respir Cell Mol Biol,2011,45(2):426-435.DOI: 10.1165/rcmb.2010-0422OC.
[33]	ZhuB,LuoGH,FengYH,et al.Apolipoprotein M protects against lipopolysaccharide-induced acute lung injury via sphingosine-1- phosphate signaling[J].Inflammation,2018,41(2):643-653.DOI: 10.1007/s10753-017-0719-x.
[34]	HuwilerA,Zangemeister-WittkeU.The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: recent findings and new perspectives[J].Pharmacol Ther,2018,185:34- 49.DOI: 10.1016/j.pharmthera.2017.11.001.
[35]	NatarajanV,DudekSM,JacobsonJR,et al.Sphingosine-1- phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury[J].Am J Respir Cell Mol Biol,2013,49(1):6-17.DOI: 10.1165/rcmb.2012-0411TR.
[36]	WangZ,KawaboriM,HoukinK.FTY720 (fingolimod) ameliorates brain injury through multiple mechanisms and is a strong candidate for stroke treatment[J].Curr Med Chem,2020,27(18):2979-2993.DOI: 10.2174/0929867326666190308133732.
[37]	SassoliC,FratiA,TaniA,et al.Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation[J].PLoS One,2014,9(9):e108662.DOI: 10.1371/journal.pone.0108662.
[38]	ChenJ,LiC,LiangZ,et al.Human mesenchymal stromal cells small extracellular vesicles attenuate sepsis-induced acute lung injury in a mouse model: the role of oxidative stress and the mitogen-activated protein kinase/nuclear factor kappa B pathway[J].Cytotherapy,2021,23(10):918-930.DOI: 10.1016/j.jcyt.2021.05.009.
[39]	ZhouZ,HuaY,DingY,et al.Conditioned medium of bone marrow mesenchymal stem cells involved in acute lung injury by regulating epithelial sodium channels via miR-34c[J].Front Bioeng Biotechnol,2021,9:640116.DOI: 10.3389/fbioe.2021.640116.
[40]	PengW,ChangM,WuY,et al.Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway[J].Stem Cell Res Ther,2021,12(1):216.DOI: 10.1186/s13287-021-02276-y.
[41]	LiuA,ZhangX,HeH,et al.Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease[J].Expert Opin Biol Ther,2020,20(2):125-140.DOI: 10.1080/14712598.2020.1689954.
[42]	BinderBY,SondergaardCS,NoltaJA,et al.Lysophosphatidic acid enhances stromal cell-directed angiogenesis[J].PLoS One,2013,8(12):e82134.DOI: 10.1371/journal.pone.0082134.
[43]	LiuH,ZhangZ,LiP,et al.Regulation of S1P receptors and sphingosine kinases expression in acute pulmonary endothelial cell injury[J].PeerJ,2016,4:e2712.DOI: 10.7717/peerj.2712.
[44]	ZhangZ, LiW, HengZ, et al. Combination therapy of human umbilical cord mesenchymal stem cells and FTY720 attenuates acute lung injury induced by lipopolysaccharide in a murine model[J]. Oncotarget, 2017,8(44):77407-77414. DOI: 10.18632/oncotarget.20491.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

Get Citation

PDF

XML

Article Metrics

Article views(73) PDF downloads(0)

Research advances of the roles of sphingosine-1-phosphate in acute lung injury

doi: 10.3760/cma.j.cn501120-20210703-00234

Abstract

References

Proportional views

Catalog

Article Metrics

Proportional views

Related

Research advances of the roles of sphingosine-1-phosphate in acute lung injury

doi: 10.3760/cma.j.cn501120-20210703-00234

Abstract

References

Proportional views

Catalog

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content