Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock

Huan Jingning; Zhang Lijun

doi:10.3760/cma.j.cn501225-20220323-00082

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Jul 2022

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JOURNAL OF MECHANICAL ENGINEERING > 2022 > 38(5): 401-407.

Huan JN,Zhang LJ.Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock[J].Chin J Burns Wounds,2022,38(5):401-407.DOI: 10.3760/cma.j.cn501225-20220323-00082.

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Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock

doi: 10.3760/cma.j.cn501225-20220323-00082

Huan Jingning^,,
Zhang Lijun

Department of Burn and Plastic Surgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China

Funds:

General Program of National Natural Science Foundation of China 81772077

General Program of Natural Science Foundation of Guangdong Province of China 2019A1515011233

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Corresponding author: Huan Jingning, Email: jnhuan@sina.com
Received Date: 23 Mar 2022
Available Online: 20 Jul 2022
Issue Publish Date: 20 May 2022

Abstract

Abstract

Microcirculatory dysfunction is an important pathophysiological change of shock. In the last decade, many researches on the mechanism of microcirculatory dysfunction have been involved in areas such as the glycocalyx damage of vascular endothelial cells, macrocirculation- microcirculation discoupling, vascular hyporeactivity, and microcirculation monitoring. Accordingly, this paper discussed how these research findings can be applied to burn patients, with the aim of alerting the clinicians to improving microcirculation, and maintaining hemodynamic coordination during the treatment of burn shock and burn septic shock. In addition, with the development of accurate and reliable microcirculation monitoring techniques, it is necessary to carry out multi-center clinical trials to reveal the clinical significance of target-oriented shock resuscitation protocol combining macrocirculatory and microcirculatory parameters.
- Burns,
- Shock,
- Microcirculatory dysfunction,
- Burn septic shock,
- Glycocalyx damage of vascular endothelial cells,
- Vascular hyporeactivity

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References(50)

References

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Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock

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Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock

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