Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Yun Yang; Danrong Hu; Yi Lu; Bingyang Chu; Xinlong He; Yu Chen; Yao Xiao; Chengli Yang; Kai Zhou; Liping Yuan; Zhiyong Qian

doi:10.1016/j.apsb.2021.08.021

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

doi: 10.1016/j.apsb.2021.08.021

a. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China;
b. West China School of Pharmacy, Sichuan University, Chengdu 610041, China

基金项目:

This work was supported by the National Natural Science Foundation of China (NSFC31930067, NSFC31771096, and NSFC31700869), the National Key Research and Development Program of China (2017YFC1103502), the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD18002, China), and the Post-Doctor Research Project, West China Hospital, Sichuan University (No.19HXBH099, China). The authors thank Dr. Zhongqin Yan from the West China School of Pharmacy, Sichuan University, China for the PAI observation and analysis of the data.

详细信息

通讯作者:
Zhiyong Qian,E-mail:zhiyongqian@scu.edu.cn

中图分类号: https://www.sciencedirect.com/science/article/pii/S2211383521003117/pdf?md5=c450d22e8b943677c6e7c08deab689a1&pid=1-s2.0-S2211383521003117-main.pdf
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出版历程
- 收稿日期: 2021-05-24
- 修回日期: 2021-07-09
- 录用日期: 2021-08-02
- 网络出版日期: 2023-03-17

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

a. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China;
b. West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Funds:

摘要

摘要: Breast cancer has become the most commonly diagnosed cancer type in the world. A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for breast cancer therapy. However, the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Therefore, to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect, a multifunctional nanoparticle system (PCRHNs) is developed, which is grafted onto the prussian blue nanoparticles (PB NPs) by reduction-responsive camptothecin (CPT) prodrug copolymer, and then modified with tumor-targeting peptide cyclo(Asp-d-Phe-Lys-Arg-Gly) (cRGD) and hyaluronic acid (HA). PCRHNs exhibited nano-sized structure with good monodispersity, high load efficiency of CPT, triggered CPT release in response to reduction environment, and excellent photothermal conversion under laser irradiation. Furthermore, PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT. In vivo studies indicate that PCRHNs exhibited excellent biocompatibility, prolonged blood circulation, enhanced tumor accumulation, allow tumor-specific chemo-photothermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity. Moreover, hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT. Collectively, PCRHNs may be a promising therapeutic way for breast cancer therapy.
- Breast cancer /
- Chem-photothermal combinational therapy /
- Camptothecin /
- Prussian blue nanoparticles /
- Reduction-responsive prodrugs
Abstract: Breast cancer has become the most commonly diagnosed cancer type in the world. A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for breast cancer therapy. However, the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Therefore, to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect, a multifunctional nanoparticle system (PCRHNs) is developed, which is grafted onto the prussian blue nanoparticles (PB NPs) by reduction-responsive camptothecin (CPT) prodrug copolymer, and then modified with tumor-targeting peptide cyclo(Asp-d-Phe-Lys-Arg-Gly) (cRGD) and hyaluronic acid (HA). PCRHNs exhibited nano-sized structure with good monodispersity, high load efficiency of CPT, triggered CPT release in response to reduction environment, and excellent photothermal conversion under laser irradiation. Furthermore, PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT. In vivo studies indicate that PCRHNs exhibited excellent biocompatibility, prolonged blood circulation, enhanced tumor accumulation, allow tumor-specific chemo-photothermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity. Moreover, hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT. Collectively, PCRHNs may be a promising therapeutic way for breast cancer therapy.
- Breast cancer /
- Chem-photothermal combinational therapy /
- Camptothecin /
- Prussian blue nanoparticles /
- Reduction-responsive prodrugs

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Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

doi: 10.1016/j.apsb.2021.08.021

通讯作者:
Zhiyong Qian,E-mail:zhiyongqian@scu.edu.cn

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Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

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Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

doi: 10.1016/j.apsb.2021.08.021

通讯作者: Zhiyong Qian,E-mail:zhiyongqian@scu.edu.cn

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Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

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出版历程

目录

通讯作者:
Zhiyong Qian,E-mail:zhiyongqian@scu.edu.cn