脂肪间充质干细胞外泌体促进糖尿病创面愈合的研究进展

王一希; 陈俊杰; 岑瑛; 李正勇; 张振宇

doi:10.3760/cma.j.cn501120-20210218-00057

脂肪间充质干细胞外泌体促进糖尿病创面愈合的研究进展

doi: 10.3760/cma.j.cn501120-20210218-00057

四川大学华西医院烧伤整形科，成都　　610041

基金项目:

国家自然科学基金面上项目 81871574

四川省科技计划 2020YFS0267

四川省卫生健康委科研课题 19PJ097

详细信息

通讯作者:
张振宇，Email：zzy137731@163.com

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出版历程
- 收稿日期: 2021-02-18
- 网络出版日期: 2022-07-20
- 刊出日期: 2022-05-20

Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing

Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

Funds:

General Program of National Natural Science Foundation of China 81871574

Science and Technology Program of Sichuan Province of China 2020YFS0267

Scientific Research Project of Health Commission of Sichuan Province of China 19PJ097

More Information

Corresponding author: Zhang Zhenyu, Email: zzy137731@163.com

摘要

摘要: 糖尿病创面形成的病理机制是导致糖尿病创面愈合困难的重要原因之一，难愈的糖尿病创面为患者及社会带来沉重负担。来源于干细胞的外泌体具有与干细胞相似的促组织再生能力及更多的临床优势，逐渐在创面愈合中发挥重要作用。近年来，诸多研究显示，脂肪间充质干细胞外泌体（ADSC-EXO）通过参与糖尿病创面愈合的各个过程，促进创面愈合。该文就导致糖尿病创面愈合困难的病理机制、ADSC-EXO促进糖尿病创面愈合的相关作用机制及其应用前景进行综述。
- 糖尿病 /
- 伤口愈合 /
- 外泌体 /
- 脂肪间充质干细胞
Abstract: Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism, and refractory diabetic wounds bring heavy burdens to patients and society. Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages and are gradually playing important roles in wound healing. In recent years, researches have shown that exosomes derived from adipose-derived mesenchymal stem cells (ADSC-EXOs) can promote the healing of diabetic wounds by participating in various processes of wound healing. This article reviews the pathological mechanism leading to impaired healing of diabetic wounds, the related mechanism and the application prospect of ADSC-EXOs in promoting diabetic wound healing.
- Diabetes mellitus /
- Wound healing /
- Exosomes /
- Adipose-derived mesenchymal stem cells
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参考文献(45)

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