负压伤口疗法在创面治疗中的临床应用及其相关研究进展

季超; 肖仕初

doi:10.3760/cma.j.cn501120-20210511-00179

负压伤口疗法在创面治疗中的临床应用及其相关研究进展

doi: 10.3760/cma.j.cn501120-20210511-00179

季超,
肖仕初^,

海军军医大学第一附属医院烧伤外科，全军烧伤研究所，上海　　200433

基金项目:

国家重点研发计划 2018YFE0194300, 2019YFA0110503

国家自然科学基金面上项目 81571897, 81871559

详细信息

通讯作者:
肖仕初，Email：huangzhuoxiao4@hotmail.com

计量
- 文章访问数: 247
- HTML全文浏览量: 99
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2021-05-11
- 网络出版日期: 2022-08-12
- 刊出日期: 2022-06-20

Clinical application and related research advances of negative pressure wound therapy in wound treatment

Ji Chao,
Xiao Shichu^,

Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Burn Institute of PLA,Shanghai 200433, China

Funds:

National Key Research and Development Program 2018YFE0194300, 2019YFA0110503

General Program of National Natural Science Foundation of China 81571897, 81871559

More Information

Corresponding author: Xiao Shichu, Email: huangzhuoxiao4@hotmail.com

摘要

摘要: 创面修复一直是临床关注的重点问题之一。近年来，负压伤口疗法（NPWT）在促进各种创面修复中发挥了越来越积极的作用，不仅被用于治疗普通急慢性创面，而且被用于封闭手术切口、皮肤移植前创面准备、移植后皮片固定以及治疗部分复杂胸腹腔创伤。该综述旨在总结NPWT在创面治疗中的临床应用及其相关最新研究进展，并对其未来发展前景进行初步探讨。
- 负压伤口疗法 /
- 伤口愈合 /
- 皮肤 /
- 临床应用
Abstract: Wound repair has always been one of the key issues of clinical concern. In recent years, negative pressure wound therapy (NPWT) has played an increasingly active role in promoting various wound repairs, not only for the treatment of common acute and chronic wounds, but also for closure of surgical incisions, preparation of wounds before skin transplantation, fixation of skin grafts after transplantation, and treatment of some complex thoracic and abdominal trauma. This review aims to summarize the clinical application of NPWT in wound treatment and the related latest research progress, and to preliminarily discuss its future development prospects.
- Negative pressure wound therapy /
- Wound healing /
- Skin /
- Clinical application

HTML全文

参考文献(49)

[1]	MorykwasMJ,SimpsonJ,PungerK,et al.Vacuum-assisted closure: state of basic research and physiologic foundation[J].Plast Reconstr Surg,2006,117(7 Suppl): S121-126.DOI: 10.1097/01.prs.0000225450.12593.12.
[2]	LancerottoL,BayerLR,OrgillDP.Mechanisms of action of microdeformational wound therapy[J].Semin Cell Dev Biol,2012,23(9):987-992.DOI: 10.1016/j.semcdb.2012.09.009.
[3]	BorgquistO,GustafssonL,IngemanssonR,et al.Micro- and macromechanical effects on the wound bed of negative pressure wound therapy using gauze and foam[J].Ann Plast Surg,2010,64(6):789-793.DOI: 10.1097/SAP.0b013e3181ba578a.
[4]	中华医学会烧伤外科学分会,《中华烧伤杂志》编辑委员会.负压封闭引流技术在烧伤外科应用的全国专家共识(2017版)[J].中华烧伤杂志,2017,33(3):129-135.DOI: 10.3760/cma.j.issn.1009-2587.2017.03.001.
[5]	JiS,LiuX,HuangJ,et al.Consensus on the application of negative pressure wound therapy of diabetic foot wounds[J/OL].Burns Trauma,2021,9:tkab018[2021-12-31].https://pubmed.ncbi.nlm.nih.gov/34212064/.DOI: 10.1093/burnst/tkab018.
[6]	HuangY,MaoB,HuJ,et al.Consensus on the health education of home-based negative pressure wound therapy for patients with chronic wounds: a modified Delphi study[J/OL].Burns Trauma,2021,9:tkab046[2021-12-31]. https://pubmed.ncbi.nlm.nih.gov/34993255/.DOI: 10.1093/burnst/tkab046.
[7]	LalezariS,LeeCJ,BorovikovaAA,et al.Deconstructing negative pressure wound therapy[J].Int Wound J,2017,14(4):649-657.DOI: 10.1111/iwj.12658.
[8]	DongJ,QingC,SongF,et al.Potential molecular mechanisms of negative pressure in promoting wound healing[J].Int Wound J,2020,17(5):1428-1438.DOI: 10.1111/iwj.13423.
[9]	YangSL,ZhuLY,HanR,et al.Effect of negative pressure wound therapy on cellular fibronectin and transforming growth factor-β1 expression in diabetic foot wounds[J].Foot Ankle Int,2017,38(8):893-900.DOI: 10.1177/1071100717704940.
[10]	ShahA,SumpioBJ,TsayC,et al.Incisional negative pressure wound therapy augments perfusion and improves wound healing in a swine model pilot study[J].Ann Plast Surg,2019,82(4S Suppl 3):S222-227.DOI: 10.1097/SAP.0000000000001842.
[11]	SongH,XuY,ChangW,et al.Negative pressure wound therapy promotes wound healing by suppressing macrophage inflammation in diabetic ulcers[J].Regen Med,2020,15(12):2341-2349.DOI: 10.2217/rme-2020-0050.
[12]	WangT,LiX,FanL,et al.Negative pressure wound therapy promoted wound healing by suppressing inflammation via down-regulating MAPK-JNK signaling pathway in diabetic foot patients[J].Diabetes Res Clin Pract,2019,150:81-89.DOI: 10.1016/j.diabres.2019.02.024.
[13]	Ludwig-SlomczynskaAH,BorysS,SewerynMT,et al.DNA methylation analysis of negative pressure therapy effect in diabetic foot ulcers[J].Endocr Connect,2019,8(11):1474-1482.DOI: 10.1530/EC-19-0373.
[14]	HasanMY,TeoR,NatherA.Negative-pressure wound therapy for management of diabetic foot wounds: a review of the mechanism of action, clinical applications, and recent developments[J].Diabet Foot Ankle,2015,6:27618.DOI: 10.3402/dfa.v6.27618.
[15]	ChanSY,WongKL,LimJX,et al.The role of Renasys-GO™ in the treatment of diabetic lower limb ulcers: a case series[J].Diabet Foot Ankle,2014,5:24718.DOI: 10.3402/dfa.v5.24718.
[16]	MouësCM,VosMC,van den BemdGJ,et al.Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial[J].Wound Repair Regen,2004,12(1):11-17.DOI: 10.1111/j.1067-1927.2004.12105.x.
[17]	StrugalaV,MartinR.Meta-analysis of comparative trials evaluating a prophylactic single-use negative pressure wound therapy system for the prevention of surgical site complications[J].Surg Infect (Larchmt),2017,18(7):810-819.DOI: 10.1089/sur.2017.156.
[18]	LandsmanA.Analysis of the SNaP Wound Care System, a negative pressure wound device for treatment of diabetic lower extremity wounds[J].J Diabetes Sci Technol,2010,4(4):831-832.DOI: 10.1177/193229681000400410.
[19]	MarstonWA,ArmstrongDG,ReyzelmanAM,et al.A multicenter randomized controlled trial comparing treatment of venous leg ulcers using mechanically versus electrically powered negative pressure wound therapy[J].Adv Wound Care (New Rochelle),2015,4(2):75-82.DOI: 10.1089/wound.2014.0575.
[20]	WeeIJY,MakM,O'DonnellG,et al. The smart negative pressure (SNaP) wound care system: a case series from Singapore[J].Int Wound J,2019,16(4):891-896.DOI: 10.1111/iwj.13114.
[21]	SrivastavaRN,DwivediMK,BhagatAK,et al.A non-randomised, controlled clinical trial of an innovative device for negative pressure wound therapy of pressure ulcers in traumatic paraplegia patients[J].Int Wound J,2016,13(3):343-348.DOI: 10.1111/iwj.12309.
[22]	TéotL,BoissiereF,FluieraruS.Novel foam dressing using negative pressure wound therapy with instillation to remove thick exudate[J].Int Wound J,2017,14(5):842-848.DOI: 10.1111/iwj.12719.
[23]	ObstMA,HarriganJ,WodashA,et al.Early-stage management of complex wounds using negative pressure wound therapy with instillation and a dressing with through holes[J].Wounds,2019,31(5):E33-E36.
[24]	NuutilaK,YangL,BroomheadM,et al.Novel negative pressure wound therapy device without foam or gauze is effective at -50 mmHg[J].Wound Repair Regen,2019,27(2):162-169.DOI: 10.1111/wrr.3.
[25]	YaoM,FabbiM,HayashiH,et al.A retrospective cohort study evaluating efficacy in high-risk patients with chronic lower extremity ulcers treated with negative pressure wound therapy[J].Int Wound J,2014,11(5):483-488.DOI: 10.1111/j.1742-481X.2012.01113.x.
[26]	FraccalvieriM,RukaE,BocchiottiMA,et al.Patient's pain feedback using negative pressure wound therapy with foam and gauze[J].Int Wound J,2011,8(5):492-499.DOI: 10.1111/j.1742-481X.2011.00821.x.
[27]	BaekW,LeeN,HanEJ,et al.A prospective randomized study: the usefulness and efficacy of negative pressure wound therapy with lipidocolloid polyester mesh compared to traditional negative pressure wound therapy for treatment of pressure ulcers[J].Pharmaceutics,2020,12(9):813.DOI: 10.3390/pharmaceutics12090813.
[28]	MirpourS,FathollahS,MansouriP,et al.Cold atmospheric plasma as an effective method to treat diabetic foot ulcers: a randomized clinical trial[J].Sci Rep,2020,10(1):10440.DOI: 10.1038/s41598-020-67232-x.
[29]	SouzaLB,SilvaJIS,BagneL,et al.Argon atmospheric plasma treatment promotes burn healing by stimulating inflammation and controlling the redox state[J].Inflammation,2020,43(6):2357-2371.DOI: 10.1007/s10753-020-01305-x.
[30]	CuiHS,JooSY,ChoYS,et al.Effect of combining low temperature plasma, negative pressure wound therapy, and bone marrow mesenchymal stem cells on an acute skin wound healing mouse model[J].Int J Mol Sci,2020,21(10):3675.DOI: 10.3390/ijms21103675.
[31]	王爱,马文国,王成德,等.自体富血小板血浆凝胶联合负压封闭引流技术治疗难愈性创面的临床效果[J].中华烧伤杂志,2021,37(1):42-48.DOI: 10.3760/cma.j.cn501120-20200105-00004.
[32]	KrtickaM,IraD,BilikA,et al.Fasciotomy closure using negative pressure wound therapy in lower leg compartment syndrome[J].Bratisl Lek Listy,2016,117(12):710-714.DOI: 10.4149/BLL_2016_136.
[33]	KimKJ,MinJH,YooI,et al.Negative pressure wound therapy for skin necrosis prevention after snakebite in the emergency department: a retrospective cohort study[J].Medicine (Baltimore),2021,100(3):e24290.DOI: 10.1097/MD.0000000000024290.
[34]	KarlakkiS,BremM,GianniniS,et al.Negative pressure wound therapy for management of the surgical incision in orthopaedic surgery: a review of evidence and mechanisms for an emerging indication[J].Bone Joint Res,2013,2(12):276-284.DOI: 10.1302/2046-3758.212.2000190.
[35]	TredgetEE,LeviB,DonelanMB.Biology and principles of scar management and burn reconstruction[J].Surg Clin North Am,2014,94(4):793-815.DOI: 10.1016/j.suc.2014.05.005.
[36]	NagataT,MiuraK,HommaY,et al.Comparison between negative-pressure fixation and film dressing in wound management after tissue expansion: a randomized controlled trial[J].Plast Reconstr Surg,2018,142(1):37-41.DOI: 10.1097/PRS.0000000000004470.
[37]	PhilipB,McCluskeyP,HinchionJ.Experience using closed incision negative pressure wound therapy in sternotomy patients[J].J Wound Care,2017,26(8):491-495.DOI: 10.12968/jowc.2017.26.8.491.
[38]	RashedA,CsiszarM,BelediA,et al.The impact of incisional negative pressure wound therapy on the wound healing process after midline sternotomy[J].Int Wound J,2021,18(1):95-102.DOI: 10.1111/iwj.13497.
[39]	LeitaoMMJr,ZhouQC,SchiavoneMB,et al.Prophylactic negative pressure wound therapy after laparotomy for gynecologic surgery: a randomized controlled trial[J].Obstet Gynecol,2021,137(2):334-341.DOI: 10.1097/AOG.0000000000004243.
[40]	MeyerJ,RoosE,AbbassiZ,et al.Prophylactic negative-pressure wound therapy prevents surgical site infection in abdominal surgery: an updated systematic review and meta-analysis of randomized controlled trials and observational studies[J].Clin Infect Dis,2021,73(11):e3804-e3813.DOI: 10.1093/cid/ciaa1203.
[41]	KuperTM,MurphyPB,KaurB,et al.Prophylactic negative pressure wound therapy for closed laparotomy incisions: a meta-analysis of randomized controlled trials[J].Ann Surg,2020,271(1):67-74.DOI: 10.1097/SLA.0000000000003435.
[42]	GuffantiA.Negative pressure wound therapy in the treatment of diabetic foot ulcers: a systematic review of the literature[J].J Wound Ostomy Continence Nurs,2014,41(3):233-237.DOI: 10.1097/WON.0000000000000021.
[43]	HehrJD,HodsonTS,WestJM,et al.Instillation negative pressure wound therapy: an effective approach for hardware salvage[J].Int Wound J,2020,17(2):387-393.DOI: 10.1111/iwj.13283.
[44]	TopazM,AshkenaziI,BarzelO,et al.Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study[J/OL].Burns Trauma,2021,9:tkab007[2021-12-31]. https://pubmed.ncbi.nlm.nih.gov/34212059/.DOI: 10.1093/burnst/tkab007.
[45]	Lorca-GarcíaC,BerenguerB,de TomásE.Use of innovative negative pressure therapy for cartilage exposure in microtia reconstruction[J].J Plast Reconstr Aesthet Surg,2019,72(2):e3-e4.DOI: 10.1016/j.bjps.2018.10.044.
[46]	BobkiewiczA,KrokowiczL,BanasiewiczT,et al.Endoscopic vacuum therapy with instillation (iEVT) - a novel endoscopic concept for colorectal anastomotic leak and perianal complications[J].Wideochir Inne Tech Maloinwazyjne,2020,15(4):560-566.DOI: 10.5114/wiitm.2020.93204.
[47]	CaiSS,GowdaAU,AlexanderRH,et al.Use of negative pressure wound therapy on malignant wounds - a case report and review of literature[J].Int Wound J,2017,14(4):661-665.DOI: 10.1111/iwj.12665.
[48]	MaklerV,LittJS,LitofskyNS.Palliative coverage of cranial defect following failed cranial flap for advanced squamous cell carcinoma: case report[J].J Palliat Med,2018,21(1):109-113.DOI: 10.1089/jpm.2017.0258.
[49]	PatelRS,WangSSY,RamosMRD,et al.Vacuum-assisted closure: an effective technique to manage wound complications after metastatic spine tumour surgery (MSTS)-a case report[J].Int J Spine Surg,2019,13(6):544-550.DOI: 10.14444/6074.