留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

类胡萝卜素生物学功能及提高其生物利用的研究进展

修伟业 黎晨晨 遇世友 王鑫 马永强

修伟业,黎晨晨,遇世友,等. 类胡萝卜素生物学功能及提高其生物利用的研究进展[J]. 食品工业科技,2023,44(10):406−415. doi: 10.13386/j.issn1002-0306.2022060309
引用本文: 修伟业,黎晨晨,遇世友,等. 类胡萝卜素生物学功能及提高其生物利用的研究进展[J]. 食品工业科技,2023,44(10):406−415. doi: 10.13386/j.issn1002-0306.2022060309
XIU Weiye, LI Chenchen, YU Shiyou, et al. Research Progress on the Biological Function and Bioavailability Improvement of Carotenoids[J]. Science and Technology of Food Industry, 2023, 44(10): 406−415. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022060309
Citation: XIU Weiye, LI Chenchen, YU Shiyou, et al. Research Progress on the Biological Function and Bioavailability Improvement of Carotenoids[J]. Science and Technology of Food Industry, 2023, 44(10): 406−415. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022060309

类胡萝卜素生物学功能及提高其生物利用的研究进展

doi: 10.13386/j.issn1002-0306.2022060309
基金项目: 哈尔滨商业大学科研项目(2019SPCX001);黑龙江省教育厅科研项目(17XN069);黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2018136)。
详细信息
    作者简介:

    修伟业(1996−),男,博士研究生,研究方向:食品营养与安全,E-mail:xiuweiye0451@163.com

    通讯作者:

    马永强(1963−),男,硕士,教授,研究方向:农产品加工及精深利用,E-mail:qyma126@163.com

  • 中图分类号: TS202.3

Research Progress on the Biological Function and Bioavailability Improvement of Carotenoids

  • 摘要: 类胡萝卜素是一种自然界中分布广泛的食品成分,具有多种生物学活性,受到诸多学者关注。文章主要从类胡萝卜素生物学功能、食品成分对类胡萝卜素吸收利用的影响及提高其生物学利用三方面综述其研究进展。类胡萝卜素具有特异性调控相关基因及蛋白的功能,进而具有多种生物活性。文章从机制的角度归纳总结类胡萝卜素的功能特性,整理了食品成分间相互作用对类胡萝卜素生物利用率的影响,总结了纳米载药系统技术、异构化处理技术以及通过食品加工方式三种提高类胡萝卜素生物利用率的方法,为类胡萝卜素功能性产品研发提供一定的理论参考。

     

  • 图  部分类胡萝卜素结构图

    注:(a)α-胡萝卜素;(b)β-胡萝卜素;(c)番茄红素;(d)叶黄素;(e)玉米黄素;(f)辣椒红素;(g)虾青素。

    Figure  1.  Structural of some carotenoids

    图  类胡萝卜素吸收转运方式

    Figure  2.  Absorption and transport of carotenoids

  • [1] HONG H, TAKAGI T, HARE T. An optimal saponification and extraction method to determine carotenoids in avocado[J]. Food Chemistry,2022,387:132923−132923. doi: 10.1016/j.foodchem.2022.132923
    [2] GÓMEZ-MAQUEO A, BANDINO E, HORMAZA J I, et al. Characterization and the impact of in vitro simulated digestion on the stability and bioaccessibility of carotenoids and their esters in two Pouteria lucuma varieties[J]. Food Chemistry,2020,316:126369. doi: 10.1016/j.foodchem.2020.126369
    [3] MELIZA L R, ISABELA S, PEDRO E D A. Ultrasound and ethanol pre-treatments to improve convective drying: Drying, rehydration and carotenoid content of pumpkin[J]. Food and Bioproducts Processing,2020,119:20−30. doi: 10.1016/j.fbp.2019.10.008
    [4] LUCAS G C, JESSICA H D, BIANCA B A, et al. Spirulina sp. LEB 18 cultivation in outdoor pilot scale using aquaculture wastewater: High biomass, carotenoid, lipid and carbohydrate production[J]. Aquaculture,2020,525:735272. doi: 10.1016/j.aquaculture.2020.735272
    [5] LARA Č, ŠEBOJKA K. Electrochemistry as a screening method in determination of carotenoids in crustacean samples used in everyday diet[J]. Food Chemistry,2020,309:125706. doi: 10.1016/j.foodchem.2019.125706
    [6] TAN K, LIU H, ZHANG H, et al. Seasonal variation of total carotenoids content in the tissues of male and female golden noble scallops Chlamys nobilis[J]. Aquaculture,2020,518(C):734796.
    [7] LINDA A, WANG Z, LI J, et al. Survival, retention rate and immunity of the black shell colored stocks of pearl oyster Pinctada fucata martensii after grafting operation[J]. Fish and Shellfish Immunology,2020,98:691−698. doi: 10.1016/j.fsi.2019.11.003
    [8] LIU H, ZHANG C, ZHANG X, et al. A novel carotenoids-producing marine bacterium from noble scallop Chlamys nobilis and antioxidant activities of its carotenoid compositions[J]. Food Chemistry,2020,320:126629. doi: 10.1016/j.foodchem.2020.126629
    [9] BRITTON G. Carotenoid research: History and new perspectives for chemistry in biological systems[J]. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids,2020:158699.
    [10] BONET M L, RIBOT J, GALMÉS S, et al. Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies[J]. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids,2020,1865(11):158676. doi: 10.1016/j.bbalip.2020.158676
    [11] 郑梦熳, 李文韵, 刘雨薇. 类胡萝卜素肠道吸收及生物利用度研究进展[J]. 食品工业科技,2021,42(15):403−411. [ZHENG M M, LI W Y, LIU Y W. Research progress on intestinal absorption and bioavailability of carotenoids[J]. Science and Technology of Food Industry,2021,42(15):403−411. doi: 10.13386/j.issn1002-0306.2020070335
    [12] 陈叶, 戴竹青, 宋江峰, 等. 胶束化对Caco-2上皮细胞叶黄素吸收和转运的影响[J]. 食品工业科技, 2019, 40(20): 304-309. CHEN Y, DAI Z, SONG J, et al. , Effect of micellization on lutein absorption and transportation in Caco-2 epithelial cells[J]. Science and Technology of Food Industry, 2019, 40(20): 304-309. ]
    [13] BRAULIO C, JOSÉ de J O, SAUL R, et al. Effects of pectin on lipid digestion and possible implications for carotenoid bioavailability during pre-absorptive stages: A review[J]. Food Research International,2017,99(2):917−927.
    [14] MÉLANIE C, ANDREIA A, ANA C, et al. Lycopene in human health[J]. LWT,2020,127:109323−109323. doi: 10.1016/j.lwt.2020.109323
    [15] SUNA K, TAE Y H, IN K H. Analysis, bioavailability, and potential healthy effects of Capsanthin, natural red pigment from Capsicum spp.[J]. Food Reviews International,2009,25(3):198−213. doi: 10.1080/87559120902956141
    [16] KRINSKY N I. Antioxidant functions of carotenoids[J]. Free Radical Biology and Medicine,1989,7(6):617−635. doi: 10.1016/0891-5849(89)90143-3
    [17] YONAR S M, YONAR M E, PALA A, et al. Effect of trichlorfon on some haematological and biochemical changes in Cyprinus carpio: The ameliorative effect of lycopene[J]. Aquaculture Reports,2020,16:100246. doi: 10.1016/j.aqrep.2019.100246
    [18] XIE J, FANG H, HE X, et al. Study on mechanism of synthetic astaxanthin and Haematococcus pluvialis improving the growth performance and antioxidant capacity under acute hypoxia stress of golden pompano (Trachinotus ovatus) and enhancing anti-inflammatory by activating Nrf2-ARE pathway to antagonize the NF-κB pathway[J]. Aquaculture,2020:518.
    [19] KOJI S, TAKASHI I, RISA H, et al. Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population[J]. Clinical Nutrition,2006,25(5):780−789. doi: 10.1016/j.clnu.2006.01.025
    [20] WANG N, WANG D, ZHOU J, et al. Lutein prevents the excessive fat deposition in liver and abdominal tissues by activating SIRT1 and up-regulating ATGL and HSL in high fat diet rats (FS06-01-19)[J]. Current Developments in Nutrition, 2019, 3(1).
    [21] TIAN H, LIU G, GUO Y, et al. Lycopene supplementation regulates the gene expression profile and fat metabolism of breeding hens[J]. Journal of Animal Physiology and Animal Nutrition,2020,104(3):936−945. doi: 10.1111/jpn.13344
    [22] WANG J, GENG T, ZOU Q, et al. Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function[J]. Journal of Functional Foods,2020,67:103857. doi: 10.1016/j.jff.2020.103857
    [23] WU T, GAO Y, HAO J, et al. Capsanthin extract prevents obesity, reduces serum TMAO levels and modulates the gut microbiota composition in high-fat-diet induced obese C57BL/6J mice[J]. Food Research International,2020,128:108774. doi: 10.1016/j.foodres.2019.108774
    [24] FATEMEH H, ABDOLLAH H, BIZHAN H, et al. An energy-restricted high-protein diet supplemented with β-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: A randomized controlled trial[J]. Nutrition Research,2020:73.
    [25] LIN P, REN Q, WANG Q, et al. Carotenoids inhibit fructose-induced inflammatory response in human endothelial cells and monocytes[J]. Mediators of Inflammation,2020,2020:5373562.
    [26] TOM L, ZHE L, MARINE N. Lutein and zeaxanthin supplement use is associated with increased macular pigment density over 15 years and greater contrast sensitivity in the carotenoids in age-related eye disease study of older-adult women[J]. Investigative Ophthalmology & Visual Science,2021,62(8):2950.
    [27] ZHAO S, LAN X, WU J, et al. Protocol of global incidence and progression of age-related macular degeneration: A systematic review[J]. Medicine,2019,98(10):e14645. doi: 10.1097/MD.0000000000014645
    [28] MA L, YAN S, HUANG Y, et al. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration[J]. Ophthalmology,2012,119(11):2290−2297. doi: 10.1016/j.ophtha.2012.06.014
    [29] KARAKURT Y, SÜLEYMAN H, KESKIN C F, et al. The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: An experimental study[J]. Cutaneous and Ocular Toxicology,2019,38(2):136−140. doi: 10.1080/15569527.2018.1539010
    [30] IBRAHIM A E, SHAFAA M W, KHEDR M H, et al. Comparative study between lutein and its liposomal form on cisplatin-induced retinal injury in rabbits[J]. Cutaneous and Ocular Toxicology,2019,38(3):279−285. doi: 10.1080/15569527.2019.1608227
    [31] SAHIN K, GENCOGLU H, AKDEMIR F, et al. Lutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage via modulation of G protein-coupled receptors and growth factors in rats[J]. Biochemical and Biophysical Research Communications,2019,516(1):163−170. doi: 10.1016/j.bbrc.2019.06.032
    [32] REN Y, QI Y, SU X, et al. Therapeutic effect of lutein supplement on non-proliferative diabetic retinopathy: A retrospective study[J]. Medicine,2019,98(29):e15404. doi: 10.1097/MD.0000000000015404
    [33] GE Y, ZHANG A, SUN R, et al. Penetratin modified lutein nanoemulsion in-situ gel for the treatment of age-related macular degeneration[J]. Expert Opinion on Drug Delivery,2020,17(4):603−619. doi: 10.1080/17425247.2020.1735348
    [34] SAWA M, SHUNTO T, NISHIYAMA I, et al. Effects of lutein supplementation in Japanese patients with unilateral age-related macular degeneration: The sakai lutein study[J]. Scientific Reports,2020,10(1):5958. doi: 10.1038/s41598-020-62483-0
    [35] XU X, TENG Y, ZOU J, et al. Effects of lycopene on vascular remodeling through the LXR-PI3K-AKT signaling pathway in APP/PS1 mice[J]. Biochemical and Biophysical Research Communications,2020,526(3):699−705. doi: 10.1016/j.bbrc.2020.02.063
    [36] ZHU N, YIN X, LIN R, et al. Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia[J]. Neural Regeneration Research,2020,15(2):332−341. doi: 10.4103/1673-5374.265565
    [37] ZENI A L B, CAMARGO A, DALMAGRO A P. Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[J]. Pharmacology, Biochemistry, and Behavior,2019,179:63−72. doi: 10.1016/j.pbb.2019.02.004
    [38] RICCIONI G. Carotenoids and cardiovascular disease[J]. Current Atherosclerosis Reports,2009,11(6):434−439. doi: 10.1007/s11883-009-0065-z
    [39] OUYANG B, LI Z, JI X, et al. The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway[J]. Pharmaceutical Biology,2019,57(1):529−535. doi: 10.1080/13880209.2019.1649436
    [40] ZENG J, ZHAO J, DONG B, et al. Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress[J]. The Journal of Nutritional Biochemistry,2019,66:70−78. doi: 10.1016/j.jnutbio.2019.01.002
    [41] ROWLES J L, ERDMAN J W. Carotenoids and their role in cancer prevention[J]. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids,2020,1865(11):158613. doi: 10.1016/j.bbalip.2020.158613
    [42] 陈金东. 中国各类癌症的发病率和死亡率现状及发展趋势[J]. 遵义医学院学报,2018,41(6):653−662. [CHEN J. Trends of cancer incidence and mortality in China[J]. Journal of Zunyi Medical University,2018,41(6):653−662. doi: 10.3969/j.issn.1000-2715.2018.06.001
    [43] WANG S, WU Y, WANG X, et al. Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation[J]. Aging,2020,12(9):8167−8190. doi: 10.18632/aging.103132
    [44] MAZIDI M, FERNS G A, BANACH M. A high consumption of tomato and lycopene is associated with a lower risk of cancer mortality: Results from a multi-ethnic cohort[J]. Public Health Nutrition,2020,23(9):1569−1575. doi: 10.1017/S1368980019003227
    [45] TAKUJI T, MASAHITO S, HISATAKA M. Cancer chemoprevention by carotenoids[J]. Molecules,2012,17(3):3202−3242. doi: 10.3390/molecules17033202
    [46] ZHANG Y, ZHU X, HUANG T, et al. β-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro[J]. Toxicology Letters,2016,261:49−58. doi: 10.1016/j.toxlet.2016.08.010
    [47] KAVALAPPA Y P, RUDRESH D U, GOPAL S S, et al. β-carotene isolated from the marine red alga, Gracillaria sp. potently attenuates the growth of human hepatocellular carcinoma (HepG2) cells by modulating multiple molecular pathways[J]. Journal of Functional Foods,2019,52:165−176. doi: 10.1016/j.jff.2018.11.015
    [48] JIANG X, WU H, ZHAO W, et al. Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells[J]. Cancer Cell International,2020,12(9):8167−8190.
    [49] LIU F, QU Y, WANG A, et al. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress[J]. Aquaculture,2019,503:293−303. doi: 10.1016/j.aquaculture.2019.01.008
    [50] ZHANG J, WANG P, XU F, et al. Protective effects of lycopene against AFB1-induced erythrocyte dysfunction and oxidative stress in mice[J]. Research in Veterinary Science,2020,129:103−108. doi: 10.1016/j.rvsc.2020.01.015
    [51] MAIANI G, PERIAGO C M J, CATASTA G, et al. Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans[J]. Molecular Nutrition & Food Research,2009,53:S194−S218.
    [52] CASTENMILLER J, WEST C, LINSSEN J, et al. The food matrix of spinach is a limiting factor in determining the bioavailability of β-carotene and to a lesser extent of lutein in humans[J]. The Journal of Nutrition,1999,129:349−355. doi: 10.1093/jn/129.2.349
    [53] ZHAO C, WEI L, YIN B, et al. Encapsulation of lycopene within oil-in-water nanoemulsions using lactoferrin: Impact of carrier oils on physicochemical stability and bioaccessibility[J]. International Journal of Biological Macromolecules,2020,153:912−920. doi: 10.1016/j.ijbiomac.2020.03.063
    [54] MASAKI H, KAZUYA M, YO W, et al. The E/Z isomer ratio of lycopene in foods and effect of heating with edible oils and fats on isomerization of (all-E)-lycopene[J]. European Journal of Lipid Science and Technology,2017,119(8).
    [55] FRANKJEN Y de B, ARNOUT I, KRASSIMIR P V. Photo-stability of lutein in surfactant-free lutein-zein composite colloidal particles[J]. Food Chemistry:X,2020,5:100071. doi: 10.1016/j.fochx.2019.100071
    [56] STEINER B M, SHUKLA V, MCCLEMENTS D J, et al. Encapsulation of lutein in nanoemulsions stabilized by resveratrol and Maillard conjugates[J]. Journal of Food Science,2019,84(9):2421−2431. doi: 10.1111/1750-3841.14751
    [57] YAN Y, ZHU Q, DIAO J, et al. Enhanced physicochemical stability of lutein-enriched emulsions by polyphenol-protein-polysaccharide conjugates and fat-soluble antioxidant[J]. Food Hydrocolloids,2020,101(C).
    [58] CHIN P T, IMEDEDDINE A N, NAVIDEH A. Protection of astaxanthin in astaxanthin nanodispersions using additional antioxidants[J]. Molecules,2013,18(7):.7699−7710. doi: 10.3390/molecules18077699
    [59] LING C, WALLACE Y, RONG L, et al. Enzymatic degradation and bioaccessibility of protein encapsulated β-carotene nano-emulsions during in vitro gastro-intestinal digestion[J]. Food Hydrocolloids,2020,100(C):105177−105177.
    [60] YI J, FAN Y, WALLACE Y, et al. Characterization of milk proteins–lutein complexes and the impact on lutein chemical stability[J]. Food Chemistry,2016,200:91−97. doi: 10.1016/j.foodchem.2016.01.035
    [61] NIE M, ZHANG Z, LIU C, et al. Hesperetin and hesperidin improved β-carotene incorporation efficiency, intestinal cell uptake, and retinoid concentrations in tissues[J]. Journal of Agricultural and Food Chemistry,2019,67(12):3363−3371. doi: 10.1021/acs.jafc.9b00551
    [62] MARQUES M C, HACKE A, NETO C A C, et al. Impact of phenolic compounds in the digestion and absorption of carotenoids[J]. Current Opinion in Food Science,2021,39:190−196. doi: 10.1016/j.cofs.2021.03.006
    [63] MENG Q, LONG P, ZHOU J, et al. Improved absorption of β-carotene by encapsulation in an oil-in-water nanoemulsion containing tea polyphenols in the aqueous phase[J]. Food Research International,2018,116:731−736.
    [64] LIU G, ZHOU Y, CHEN L. Intestinal uptake of barley protein-based nanoparticles for β-carotene delivery[J]. Acta Pharmaceutica Sinica B,2019,9(1):87−96. doi: 10.1016/j.apsb.2018.10.002
    [65] GAZIANO J M, JOHNSON E J, RUSSELL R M, et al. Discrimination in absorption of transport of β-carotene isomers following oral supplemen tation with either all-trans or 9-cis β-carotene[J]. The American Journal of Clinical Nutrition,1995,61:1248−1254. doi: 10.1093/ajcn/61.6.1248
    [66] MOSHA T, PACE R, ADEYEYE S, et al. Effect of traditional processing practices on the content of total carotenoid, β-carotene, α-carotene and vitamin A activity of selected Tanzanian vegetables[J]. Plant Foods for Human Nutrition,1997,50(3):189−201. doi: 10.1007/BF02436056
    [67] ROHMAH M, RAHMADI A, RAHARJO S. Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein[J]. Heliyon,2022,8(2):e08913. doi: 10.1016/j.heliyon.2022.e08913
    [68] NIU B, SHAO P, SUN P. Ultrasound-assisted emulsion electrosprayed particles for the stabilization of β-carotene and its nutritional supplement potential[J]. Food Hydrocolloids,2020,102(C):105634−105634.
    [69] ABDUR R, TONG Q, SEID M, et al. Carotenoid-loaded nanocarriers: A comprehensive review[J]. Advances in Colloid and Interface Science,2020,275:102048. doi: 10.1016/j.cis.2019.102048
    [70] HAN J, ZHANG Z, SHANG W, et al. Modulation of physicochemical stability and bioaccessibility of β-carotene using alginate beads and emulsion stabilized by scallop (Patinopecten yessoensis) gonad protein isolates[J]. Food Research International,2020,129(C):108875.
    [71] BA C, FU Y, NIU F, et al. Effects of environmental stresses on physiochemical stability of β-carotene in zein-carboxymethyl chitosan-tea polyphenols ternary delivery system[J]. Food Chemistry,2020,311(C):125878.
    [72] ZHONG L, MA N, WU Y, et al. Gastrointestinal fate and antioxidation of β-carotene emulsion prepared by oat protein isolate-Pleurotus ostreatus β-glucan conjugate[J]. Carbohydrate Polymers,2019,221:10−20. doi: 10.1016/j.carbpol.2019.05.085
    [73] DU Y, BAO C, HUANG J, et al. Improved stability, epithelial permeability and cellular antioxidant activity of β-carotene via encapsulation by self-assembled α-lactalbumin micelles[J]. Food Chemistry,2019,271:707−714. doi: 10.1016/j.foodchem.2018.07.216
    [74] HU Q, HU S, ERIKA F, et al. Chitosan-caseinate-dextran ternary complex nanoparticles for potential oral delivery of astaxanthin with significantly improved bioactivity[J]. International Journal of Biological Macromolecules,2020,151:747−756. doi: 10.1016/j.ijbiomac.2020.02.170
    [75] GUO Y, MAO X, ZHANG J, et al. Oral delivery of lycopene-loaded microemulsion for brain-targeting: Preparation, characterization, pharmacokinetic evaluation and tissue distribution[J]. Drug Delivery,2019,26(1):1191−1205. doi: 10.1080/10717544.2019.1689312
    [76] YUAN Y, LI H, LIU C, et al. Fabrication and characterization of lutein-loaded nanoparticles based on zein and sophorolipid: Enhancement of water solubility, stability, and bioaccessibility[J]. Journal of Agricultural & Food Chemistry,2019,67(43):11977−11985.
    [77] YOSHIKI S, KODAI U, HIROKI S, et al. Development of novel lutein nanocrystal formulation with improved oral bioavailability and ocular distribution[J]. Journal of Functional Foods,2019,61:103499. doi: 10.1016/j.jff.2019.103499
    [78] KOBAYASHI J, TOMINAGA E, OZEKI M, et al. Randomized controlled trial of a water-soluble formulation of lutein in humans[J]. Bioscience, Biotechnology, and Biochemistry,2019:2372−2374.
    [79] JHAN S, PETHE A M. Double-loaded liposomes encapsulating lycopene β-cyclodextrin complexes: Preparation, optimization, and evaluation[J]. Journal of liposome research,2019:80−92.
    [80] GASA-FALCON A, ODRIOZOLA-SERRANO I, OMS-OLIU G, et al. Impact of emulsifier nature and concentration on the stability of β-carotene enriched nanoemulsions during in vitro digestion[J]. Food & Function,2019,10(2):713−722.
    [81] YU W, LIU J. Astaxanthin isomers: Selective distribution and isomerization in aquatic animals[J]. Aquaculture,2020,520:734915. doi: 10.1016/j.aquaculture.2019.734915
    [82] HOCK-ENG K K, NAGENDRA P, KIN-WENG K, et al. Carotenoids and their isomers: Color pigments in fruits and vegetables[J]. Molecules,2011,16(2):1710. doi: 10.3390/molecules16021710
    [83] HONDA M, TAKAHASHI N, KUWA T, et al. Spectral characterisation of Z-isomers of lycopene formed during heat treatment and solvent effects on the E/Z isomerisation process[J]. Food Chemistry,2015,171:323−329. doi: 10.1016/j.foodchem.2014.09.004
    [84] MURAKAMI K, HONDA M, TAKEMURA R, et al. Effect of thermal treatment and light irradiation on the stability of lycopene with high Z-isomers content[J]. Food Chemistry,2018,250:253−258. doi: 10.1016/j.foodchem.2018.01.062
    [85] MONICA A, FRANCESCA B, AGNESE P, et al. Effect of ultrasound treatment, oil addition and storage time on lycopene stability and in vitro bioaccessibility of tomato pulp[J]. Food Chemistry,2015,172:685−691. doi: 10.1016/j.foodchem.2014.09.140
    [86] SUN Q, YANG C, LI J, et al. Lycopene: Heterogeneous catalytic E/Z isomerization and in vitro bioaccessibility assessment using a diffusion model[J]. Journal of Food Science,2016,81(10):C2381−C2389. doi: 10.1111/1750-3841.13419
    [87] HONDA M, NAKAYAMA Y, NISHIKAWA S, et al. Z-Isomers of lycopene exhibit greater liver accumulation than the all- E-isomer in mice[J]. Bioscience, Biotechnology, and Biochemistry,2020,84(2):428−431. doi: 10.1080/09168451.2019.1677144
    [88] YANG C, LIU H, SUN Q, et al. Enriched Z -isomers of lycopene-loaded nanostructured lipid carriers: Physicochemical characterization and in vitro bioaccessibility assessment using a diffusion model[J]. LWT,2019,111:767−773. doi: 10.1016/j.lwt.2019.05.106
    [89] HONDA M, ISHIKAWA H, HAYASHI Y. Alterations in lycopene concentration and Z-isomer content in egg yolk of hens fed all-E-isomer-rich and Z-isomer-rich lycopene[J]. Animal Science Journal,2019,90(9):1261−1269. doi: 10.1111/asj.13276
    [90] YANG C, FISCHER M, KIRBY C, et al. Bioaccessibility, cellular uptake and transport of luteins and assessment of their antioxidant activities[J]. Food Chemistry,2018,249:66−76. doi: 10.1016/j.foodchem.2017.12.055
    [91] WEINRICH T, XU Y, WOSU C, et al. Mitochondrial function, mobility and lifespan are improved in drosophila melanogaster by extracts of 9- cis -β-carotene from Dunaliella salina[J]. Marine Drugs,2019,17(5):279−279. doi: 10.3390/md17050279
    [92] DURING A, HUSSAIN M M, MOREL D W, et al. Carotenoid uptake and secretion by Caco-2 cells: β-carotene isomer selectivity and carotenoid interactions[J]. Journal of Lipid Research,2002,43(7):.1086−1095. doi: 10.1194/jlr.M200068-JLR200
    [93] MASAKI H, TOMOHIKO K, HAKUTO K, et al. Enhanced solubility and reduced crystallinity of carotenoids, β-carotene and astaxanthin, by Z-isomerization[J]. European Journal of Lipid Science and Technology,2018,120(11):1800191.
    [94] YU J, GLEIZE B, ZHANG L, et al. Heating tomato puree in the presence of lipids and onion: The impact of onion on lycopene isomerization[J]. Food chemistry,2019,296:9−16. doi: 10.1016/j.foodchem.2019.05.188
    [95] VAMOUGNE K, MU T, ZHANG M, et al. Effects of cooking process on carotenoids and antioxidant activity of orange-fleshed sweet potato[J]. LWT,2019,104:134−141. doi: 10.1016/j.lwt.2019.01.011
    [96] SHINJAE P, SAEHUN M, YONG-RO K. Effect of xanthan gum on lipid digestion and bioaccessibility of β-carotene-loaded rice starch-based filled hydrogels[J]. Food Research International,2018,105:440−445. doi: 10.1016/j.foodres.2017.11.039
    [97] DING Y, LIU X, BI J, et al. Effects of pectin, sugar and pH on the β-carotene bioaccessibility in simulated juice systems[J]. LWT,2020,124(C):109125−109125.
  • 加载中
图(2)
计量
  • 文章访问数:  11
  • HTML全文浏览量:  26
  • PDF下载量:  0
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-06-30
  • 刊出日期:  2023-05-15

目录

    /

    返回文章
    返回