双酚类化合物对机体影响的研究进展

兰天; 段国珍; 刘娜; 樊光辉; 赵成周; 杨仕兵; 祁有朝

doi:10.13386/j.issn1002-0306.2022080072

双酚类化合物对机体影响的研究进展

doi: 10.13386/j.issn1002-0306.2022080072

兰天^{1, 2, 3, 4,},
段国珍²,
刘娜^{1, 3, 4},
樊光辉²,
赵成周³,
杨仕兵⁴,
祁有朝^{1, 2, 3, 4,*, ,}

1.
青海大学农牧学院，青海西宁 810016
2.
青海大学农林科学院，青海西宁 810016
3.
青海大学藏医学院，青海西宁 810016
4.
青海大学医学院，青海西宁 810016

基金项目: 青海省科技基础研究计划青年项目（2021-ZJ-962Q）；2020年度青海大学青年科研基金项目（2020-QNY-3）；县域创新试点县建设专项（2020-0407-NCC-0001）。

详细信息

作者简介:
兰天（1998−），女，硕士研究生，研究方向：药理学与毒理学，E-mial：1289495380@qq.com

通讯作者:
祁有朝（1990−），男，博士，副教授，研究方向：药理学与毒理学，E-mail：yaolixueyouchao@163.com

中图分类号: TS201.6
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- 文章访问数: 64
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- 被引次数: 0
出版历程
- 收稿日期: 2022-08-09
- 刊出日期: 2023-05-15

Research Progress on the Effects of Bisphenol Compounds on Human Beings and Animals

LAN Tian^{1, 2, 3, 4
,},
DUAN Guozhen²,
LIU Na^{1, 3, 4},
FAN Guanghui²,
ZHAO Chengzhou³,
YANG Shibing⁴,
QI Youchao^{1, 2, 3, 4,*
, ,}

1.
College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China
2.
College of Agriculture and Forestry, Qinghai University, Xining 810016, China
3.
College of Tibetan Medicine, Qinghai University, Xining 810016, China
4.
College of Medical, Qinghai University, Xining 810016, China

摘要

摘要: 双酚类化合物（Bisphenol compounds，BPs）是合成高分子材料的重要原材料之一。目前，常见的双酚类化合物主要包括双酚A、双酚B、双酚F以及双酚AF等。现如今，双酚类化合物主要应用于塑料制品、食品包装、饮用水添加剂、海鲜等方面。大量的研究发现，双酚类化合物通过物理迁移、化学迁移、生物迁移途径侵入人类和动物体内，甚至在深海哺乳动物体内也检测到了该物质，从而影响了机体的生殖系统、神经系统、消化系统、心血管系统、行为、发育和代谢性疾病的发生发展。因此，双酚类化合物引起了更多的关注。因此，本文主要从BPs的分类、侵入机体的途径以及对机体的影响方面进行了综述，以期对BPs的进一步研究以及安全性和毒理学评价提供参考依据。
- 双酚类化合物 /
- 分类 /
- 侵入途径 /
- 机体影响 /
- 作用机制
Abstract: Bisphenol compounds (BPs) are one of the most significant raw materials, used in synthesizing high polymer materials. At present, common BPs mainly include bisphenol A, bisphenol B, bisphenol F, bisphenol AF and so on. Nowadays, BPs are principally applied in plastic products, the food packaging, drinking water additives, seafood and other fields. A large number of studies have found that BPs penetrate into human beings and animals by physical migration, chemical migration, biological migration and it even have been detected in deep-sea mammals, affecting the mechanisms of the reproductive system, central nervous system, digestive system, cardiovascular system, behavior, development, and metabolic diseases. Therefore, BPs have been attracting more attention. In the review, the classification, invasive pathway to foods of BPs, and its implication on human beings and animals are systematically reviewed, hoping to provide reference for the safety and toxicological evaluation of BPs.
- bisphenol compounds /
- classification /
- invasion pathways /
- effects on human beings and animals /
- mechanism

HTML全文

图 1 双酚类化合物的结构

Figure 1. Structure of BPs

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图 2 双酚类化合物入侵食品的途径

Figure 2. Invasion pathways of BPs into foods

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图 3 双酚类化合物对机体的作用

Figure 3. Effects of BPs on the human beings and animals

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图 4 BPs信号转导通路

Figure 4. Bisphenols signal transduction pathways

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表 1 双酚类化合物的结构与侵入方式

Table 1. Structure and invasion pathways of BPs

名称	分子式	分子结构	侵入方式	侵入途径	参考文献
双酚A（BPA） Bisphenol A	C₁₅H₁₆O₂		物理迁移化学迁移生物迁移	皮肤和粘膜消化道呼吸道	[13]
双酚B（BPB） Bisphenol B	C₁₆H₁₈O₂				[16−17]
双酚C（BPC） Bisphenol C	C₁₇H₂₀O₂				[25]
双酚E（BPE） Bisphenol E	C₁₄H₁₄O₂				[26]
双酚F（BPF） Bisphenol F	C₁₃H₁₂O₂				[27]
双酚P（BPP） Bisphenol P	C₂₄H₂₆O₂				[26]
双酚S（BPS） Bisphenol S	C₁₂H₁₀O₄S				[28]
双酚Z（BPZ） Bisphenol Z	C₁₈H₂₀O₂				[29]
双酚AF（BPAF） Bisphenol AF	C₁₅H₁₀F₆O₂				[23]
双酚AP（BPAP） Bisphenol AP	C₂₀H₁₈O₂				[30]
四溴双酚A（TBBPA） Tetrabromo bisphenol A	C₁₅H₁₂Br₄O₂				[31]
四氯双酚A（TCBPA） Tetrachloro bisphenol A	C₁₅H₁₂Cl₄O₂				[32]

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表 2 BPs对生殖系统的影响

Table 2. Effects of BPs on the reproductive system

研究类型（模型）		BPs	浓度	影响	参考文献
体外	牛卵母细胞和精子	BPA，BPS，BPF	0.05 mg/mL	BPA处理：活性氧升高，重组人线粒体超氧化物歧化酶-2、谷胱甘肽过氧化物酶1、谷胱甘肽过氧化物酶4基因及蛋白表达降低；BPF、BPS处理：精子产量减少	[41]
体外	人类精子	BPA	0，10⁻³，10⁻²，10⁻¹，10，10³ nmol/L	精子活力、进行性运动和黄体酮诱导的顶体反应显着下降	[42]
体内	雄性大鼠	BPS	0.5，5，50 μg/L	精子活力、产量、附睾中精子数量减少；血浆睾酮、黄体生成素、卵泡刺激素浓度降低，雌二醇水平升高；睾丸中氧化应激水平升高	[43]
体内	成年雄性小鼠	BPA	5，50 mg/kg bw/day	生殖细胞比例异常、睾丸形态改变、精元干细胞功能特性丧失	[44]
体外	小鼠卵母细胞	BPA，BPF	5，25，50 μg/mL	纺锤体缩短，微管附着减少	[45]
体内	成年雄性大鼠	BPF	1，5，25，50 mg/kg/d	精子减少，睾丸激素分泌物水平降低	[46]
体内	雌性和雄性斑马鱼	BPB	0.001，0.01，0.1，1 mg/L	鱼卵数量减少，孵化率及存活率降低，生殖功能受损	[47]
体内	雌性和雄性斑马鱼	BPAF	0.05，0.25，1 mg/L	雄性斑马睾酮水平降低，鱼E2水平升高；雌性斑马鱼睾酮分泌增加	[48]

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表 3 BPs对胚胎发育的影响

Table 3. Effects of BPs on embryonic development

BPs	模型	暴露浓度	结果	参考文献
BPAP	斑马鱼	200 μg/L	鱼卵孵化率降低、死亡率升高、卵黄囊水肿比例增高、心率降低、出现心脏环化障碍	[56]
BPA	热带非洲爪蟾	25，50，100 μmol/L	发育迟缓、胚孔异常闭合、尾部弯曲、心包水肿、体长缩短	[52]
BPABPSBPAFTMBPF	雏鸡胚胎	0.03，0.3，3，30 μmol/L	抑制体长及体重的增长，躯干四肢及器官发育畸形，胚胎存活率降低	[57]
BPABPSBPAF	胚胎干细胞	1，10 ng/mL	抑制胚胎干细胞分化	[58]
BPA	非洲爪蟾	1，10，20 μmol/L	严重畸形、行为能力受损、组织器官受损、诱导DNA损伤的凋亡	[59]

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